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Tbio
GIMAP5
GTPase IMAP family member 5

Protein Summary
Description
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity). This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358647
  • ENSP00000351473
  • ENSG00000196329
  • ENST00000498181
  • ENSP00000487840

Symbol
  • IAN4L1
  • IAN5
  • IMAP3
  • IAN4
  • IAN5
  • IROD
  • IAN-5
  • IMAP3
  • HIMAP3
  • IAN4L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
molecular function
0.76
cellular component
0.72
tissue sample
0.66
tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.93   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.93   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
GIMAP4
Tbio
Family:  Enzyme
Novelty:  0.06861132
Score:  0.932
Data Source:  STRINGDB
GIMAP8
Tbio
Family:  Enzyme
Novelty:  0.13237721
Score:  0.838
Data Source:  STRINGDB
GIMAP6
Tbio
Family:  Enzyme
Novelty:  0.18744467
Score:  0.818
Data Source:  STRINGDB
GIMAP7
Tbio
Family:  Enzyme
Novelty:  0.15758026
Score:  0.791
Data Source:  STRINGDB
CD2
Tclin
Novelty:  0.00037283
Score:  0.689
Data Source:  STRINGDB
TSPAN6
Tbio
Novelty:  0.11515803
Score:  0.663
Data Source:  STRINGDB
CISD2
Tbio
Novelty:  0.01665752
Score:  0.655
Data Source:  STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
Score:  0.652
Data Source:  STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.649
Data Source:  STRINGDB
GIMAP1
Tbio
Family:  Enzyme
Novelty:  0.16238044
Score:  0.646
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
87.4
high density lipoprotein cholesterol measurement
5
4
6
83.9
sex hormone-binding globulin measurement
6
2
10
82.5
apolipoprotein A 1 measurement
2
2
2
71.6
blood metabolite measurement
2
1
2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
87.4
high density lipoprotein cholesterol measurement
6
83.9
sex hormone-binding globulin measurement
10
82.5
apolipoprotein A 1 measurement
2
71.6
blood metabolite measurement
2
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:628871
246774
Cow
GTPase IMAP family member 5
530077
Opossum
GTPase, IMAP family member 5
100017795
Species
Name
OMA
EggNOG
Inparanoid
Rat
Cow
GTPase IMAP family member 5
Opossum
GTPase, IMAP family member 5
Publication Statistics
PubMed Score 54.93
PubMed score by year
PubTator Score 11.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title