GIMAP5
GTPase IMAP family member 5
Protein Summary
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity). This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
- ENST00000358647
- ENSP00000351473
- ENSG00000196329
- ENST00000498181
- ENSP00000487840
- IAN4L1
- IAN5
- IMAP3
- IAN4
- IAN5
- IROD
- IAN-5
- IMAP3
- HIMAP3
- IAN4L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.89 | ||
molecular function | 0.76 | ||
cellular component | 0.72 | ||
tissue sample | 0.66 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.91 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 165 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.91 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 165 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0