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Tbio
MMAB
Corrinoid adenosyltransferase

Protein Summary
Description
Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA. This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000545712
  • ENSP00000445920
  • ENSG00000139428

Symbol
  • ATR
  • cob
  • cblB
  • CFAP23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.88
molecular function
0.84
virus perturbation
0.76
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.97   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.97   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
1
4
77.5
neuroticism measurement
1
1
0
5.8
61.7
apolipoprotein A 1 measurement
1
1
1
60.3
worry measurement
1
1
1
55.3
total cholesterol measurement
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
77.5
neuroticism measurement
0
5.8
61.7
apolipoprotein A 1 measurement
1
60.3
worry measurement
1
55.3
total cholesterol measurement
1
43.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylmalonic aciduria (cobalamin deficiency) cblB type
452403
Macaque
methylmalonic aciduria (cobalamin deficiency) cblB type
708973
Mouse
MGI:1924947
77697
Rat
RGD:1596242
687861
Dog
methylmalonic aciduria (cobalamin deficiency) cblB type
486310
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylmalonic aciduria (cobalamin deficiency) cblB type
Macaque
methylmalonic aciduria (cobalamin deficiency) cblB type
Mouse
Rat
Dog
methylmalonic aciduria (cobalamin deficiency) cblB type
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96EY8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defective MMAB causes methylmalonic aciduria type cblB
Reactome
Defects in cobalamin (B12) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective MMAB causes methylmalonic aciduria type cblB
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Disease
Protein-Protein Interactions (57)
1 – 10 of 57
OXLD1
Tdark
Family: Enzyme
Novelty: 23
p_int: 0.989322241
p_ni: 0.010677759
Data Source: BioPlex
TRMT61B
Tbio
Family: Enzyme
Novelty: 0.32929047
p_int: 0.949211021
p_ni: 0.05076062
p_wrong: 0.000028359
Score: 0.305
Data Source: BioPlex,STRINGDB
TEKT2
Tbio
Novelty: 0.04607893
p_int: 0.940484829
p_ni: 0.059463833
p_wrong: 0.000051338
Score: 0.201
Data Source: BioPlex,STRINGDB
MRRF
Tbio
Novelty: 0.00269663
p_int: 0.921151977
p_ni: 0.078848011
p_wrong: 1.2e-8
Score: 0.28
Data Source: BioPlex,STRINGDB
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.912869431
p_ni: 0.087130563
p_wrong: 5e-9
Data Source: BioPlex
FDPS
Tclin
Family: Enzyme
Novelty: 0.00164195
p_int: 0.891237456
p_ni: 0.108762539
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
NUDT6
Tbio
Novelty: 0.03648851
p_int: 0.873129552
p_ni: 0.12681028
p_wrong: 0.000060168
Score: 0.189
Data Source: BioPlex,STRINGDB
ECHDC2
Tdark
Family: Enzyme
Novelty: 0.50396935
p_int: 0.851327034
p_ni: 0.147742126
p_wrong: 0.000930839
Score: 0.188
Data Source: BioPlex,STRINGDB
OXNAD1
Tdark
Family: Enzyme
Novelty: 1.38777329
p_int: 0.840781707
p_ni: 0.159050329
p_wrong: 0.000167965
Score: 0.188
Data Source: BioPlex,STRINGDB
CDK5R1
Tchem
Family: Enzyme
Novelty: 0.01065962
p_int: 0.840781707
p_ni: 0.159050329
p_wrong: 0.000167965
Score: 0.157
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  60.97

PubMed score by year
PubTator Score  193.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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