You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PTCD3
Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Protein Summary
Description
Mitochondrial RNA-binding protein that has a role in mitochondrial translation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254630
  • ENSP00000254630
  • ENSG00000132300

Symbol
  • MRPS39
  • MRP-S39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.97
histone modification site profile
0.9
cell type or tissue
0.86
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pentatricopeptide repeat domain 3
VGNC:345
459374
Macaque
pentatricopeptide repeat domain 3
697081
Mouse
MGI:1917206
69956
Rat
RGD:1565582
500199
Dog
pentatricopeptide repeat domain 3
VGNC:45132
475765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pentatricopeptide repeat domain 3
Macaque
pentatricopeptide repeat domain 3
Mouse
Rat
Dog
pentatricopeptide repeat domain 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96EY7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (194)
1 – 10 of 194
TBC1D2B
Tdark
Novelty: 0.52348266
p_int: 0.999999258
p_ni: 7.41e-7
p_wrong: 1e-9
Data Source: BioPlex
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.999380864
p_ni: 0.000619136
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.99846826
p_ni: 0.00153174
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.998332677
p_ni: 0.001667323
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.99782886
p_ni: 0.00217114
Score: 0.865
Data Source: BioPlex,STRINGDB
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.990036324
p_ni: 0.009963676
Score: 0.991
Data Source: BioPlex,STRINGDB
TRMT10B
Tdark
Family: Enzyme
Novelty: 0.61950381
p_int: 0.989082475
p_ni: 0.010917525
Score: 0.656
Data Source: BioPlex,STRINGDB
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.988660255
p_ni: 0.011339745
Score: 0.998
Data Source: BioPlex,STRINGDB
AURKAIP1
Tchem
Family: Enzyme
Novelty: 0.19241693
p_int: 0.987184875
p_ni: 0.012815125
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.986411504
p_ni: 0.013588496
Score: 0.982
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.76

PubMed score by year
PubTator Score  4.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer