Tbio MVB12A Multivesicular body subunit 12A

Protein Summary

Description

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.

Uniprot Accession IDs

• Q96EY5
• Q96I18

Gene Name

• MVB12A

Ensembl ID

• ENST00000317040
• ENSP00000324810
• ENSG00000141971
• ENST00000543795
• ENSP00000444653

Symbol

• CFBP
• FAM125A
• CFBP
• FAM125A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
interacting protein	0.84
cellular component	0.83
transcription factor binding site profile	0.77
transcription factor	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.59   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.59   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0