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Tdark
TMA16
Translation machinery-associated protein 16

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358572
  • ENSP00000351380
  • ENSG00000198498

Symbol
  • C4orf43
  • C4orf43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
small molecule perturbation
0.75
transcription factor binding site profile
0.67
tissue sample
0.6
cellular component
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
28.1
body mass index
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
28.1
body mass index
1
5.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translation machinery associated 16 homolog
VGNC:727
737885
Mouse
MGI:1913532
66282
Rat
RGD:1305222
290686
Dog
translation machinery associated 16 homolog
VGNC:47418
475487
Horse
translation machinery associated 16 homolog
100068458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translation machinery associated 16 homolog
Mouse
Rat
Dog
translation machinery associated 16 homolog
Horse
translation machinery associated 16 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96EY4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (42)
1 – 10 of 42
PHF3
Tbio
Family:  Epigenetic
Novelty:  0.08898449
p_int:  0.999535781
p_ni:  0.000464136
p_wrong:  8.3e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
TNPO2
Tbio
Novelty:  0.10454262
p_int:  0.999425248
p_ni:  0.000574752
Data Source:  BioPlex
RBM12
Tbio
Novelty:  0.10430477
p_int:  0.988635126
p_ni:  0.011364874
Score:  0.228
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.970371482
p_ni:  0.028706888
p_wrong:  0.000921629
Data Source:  BioPlex
PYGB
Tchem
Family:  Enzyme
Novelty:  0.00224148
p_int:  0.96199696
p_ni:  0.038003039
Data Source:  BioPlex
PPID
Tchem
Family:  Enzyme
Novelty:  0.01068886
p_int:  0.943373465
p_ni:  0.056587703
p_wrong:  0.000038832
Score:  0.179
Data Source:  BioPlex,STRINGDB
CENPF
Tbio
Novelty:  0.00676983
p_int:  0.933719792
p_ni:  0.066280208
Score:  0.172
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.9045163
p_ni:  0.0954837
Data Source:  BioPlex
TNPO1
Tbio
Novelty:  0.01278619
p_int:  0.894770571
p_ni:  0.105229429
Score:  0.188
Data Source:  BioPlex,STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
p_int:  0.890835018
p_ni:  0.007032544
p_wrong:  0.102132438
Score:  0.188
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.75

PubMed score by year
PubTator Score  0.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer