Tbio DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial

Protein Summary

Description

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q96EY1
• B2RAJ5
• B4DI33
• E7ES32
• O75472
• Q8WUJ6
• Q8WXJ3
• Q96D76
• Q96IV1
• Q9NYH8

Gene Name

• DNAJA3

Ensembl ID

• ENST00000262375
• ENSP00000262375
• ENSG00000103423
• ENST00000355296
• ENSP00000347445
• ENST00000431375
• ENSP00000393970
• ENST00000612103
• ENSP00000477570
• ENSG00000276726
• ENST00000614397
• ENSP00000479815

Symbol

• HCA57
• TID1
• TID1
• HCA57
• hTID-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	0.98
biological process	0.94
molecular function	0.93
transcription factor binding site profile	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.85   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 249   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.85   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0