Protein Summary
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic rel ...more
- ENST00000338950
- ENSP00000344718
- ENSG00000047579
- ENST00000344537
- ENSP00000341680
- BLOC1S8
- SDY
- DBND
- HPS7
- My031
- BLOC1S8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
kinase perturbation | 0.97 | ||
cellular component | 0.91 | ||
histone modification site profile | 0.85 | ||
biological term | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.3 (req: < 5)
Gene RIFs: 127 (req: <= 3)
Antibodies: 404 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.3 (req: >= 5)
Gene RIFs: 127 (req: > 3)
Antibodies: 404 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (211)
BLOC1S3
Novelty: 0.08465735
p_int: 0.999999997
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
BLOC1S2
Novelty: 0.02346362
p_int: 0.999999992
p_ni: 8e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
TXLNB
Novelty: 0.12751933
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.536
Data Source: BioPlex,STRINGDB
BORCS8
Novelty: 1.62939642
p_int: 0.99999995
p_ni: 3.8e-8
p_wrong: 1.2e-8
Score: 0.666
Data Source: BioPlex,STRINGDB
BLOC1S1
Novelty: 0.02921036
p_int: 0.9999999
p_ni: 1e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
BLOC1S5
Novelty: 0.17565466
p_int: 0.999999843
p_ni: 4e-9
p_wrong: 1.52e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
TRIM69
Family: Enzyme
Novelty: 0.18807436
p_int: 0.999999837
p_ni: 1.63e-7
Score: 0.476
Data Source: BioPlex,STRINGDB
COG6
Novelty: 0.02874093
p_int: 0.999999799
p_ni: 2.01e-7
Score: 0.414
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Reactome | trans-Golgi Network Vesicle Budding | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Golgi Associated Vesicle Biogenesis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
trans-Golgi Network Vesicle Budding | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Components (23)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 2 | 2 | 1 | 7 | 81.6 | ||||
2 | 1 | 2 | 46.1 | ||||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 36.9 | |||||
1 | 1 | 0 | 1.1 | 24.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 7 | 81.6 | ||||
2 | 46.1 | ||||||
BMI-adjusted hip circumference | 1 | 36.9 | |||||
0 | 1.1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | dystrobrevin binding protein 1 | 709358 | ||||||
Mouse | MGI:2137586 | 94245 | ||||||
Dog | dystrobrevin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17328] | |||||||
Horse | dystrobrevin binding protein 1 | VGNC:17334 | 100065604 | |||||
Cow | dystrobrevin binding protein 1 | VGNC:28233 | 506612 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | dystrobrevin binding protein 1 | |||||
Mouse | ||||||
Dog | dystrobrevin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17328] | |||||
Horse | dystrobrevin binding protein 1 | |||||
Cow | dystrobrevin binding protein 1 | |||||
Publication Statistics
PubMed Score 336.30
PubMed score by year
PubTator Score 204.93
PubTator score by year
Related Publications
Text Mined References (180)
GeneRif Annotations (127)
Items per page:
0 of 0
PMID | Year | Title |
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