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Tbio
DTNBP1
Dysbindin

Protein Summary
Description
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic rel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338950
  • ENSP00000344718
  • ENSG00000047579
  • ENST00000344537
  • ENSP00000341680

Symbol
  • BLOC1S8
  • SDY
  • DBND
  • HPS7
  • My031
  • BLOC1S8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
kinase perturbation
0.97
cellular component
0.91
histone modification site profile
0.85
biological term
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.7   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 404   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.7   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
29.4
interleukin 10 measurement
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
29.4
interleukin 10 measurement
1
1.5
Pathways (4)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Gene Ontology Terms (40)
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (211)
1 – 10 of 211
BCAS4
Tbio
Novelty: 0.11759439
p_int: 1
Score: 0.886
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 1
Score: 0.3
Data Source: BioPlex,STRINGDB
BLOC1S3
Tbio
Novelty: 0.08465735
p_int: 0.999999997
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
BLOC1S2
Tbio
Novelty: 0.02346362
p_int: 0.999999992
p_ni: 8e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
TXLNB
Tbio
Novelty: 0.12751933
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.536
Data Source: BioPlex,STRINGDB
BORCS8
Tdark
Novelty: 1.62939642
p_int: 0.99999995
p_ni: 3.8e-8
p_wrong: 1.2e-8
Score: 0.666
Data Source: BioPlex,STRINGDB
BLOC1S1
Tbio
Novelty: 0.02921036
p_int: 0.9999999
p_ni: 1e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
BLOC1S5
Tbio
Novelty: 0.17565466
p_int: 0.999999843
p_ni: 4e-9
p_wrong: 1.52e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
TRIM69
Tbio
Family: Enzyme
Novelty: 0.18807436
p_int: 0.999999837
p_ni: 1.63e-7
Score: 0.476
Data Source: BioPlex,STRINGDB
COG6
Tbio
Novelty: 0.02874093
p_int: 0.999999799
p_ni: 2.01e-7
Score: 0.414
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  331.70

PubMed score by year
PubTator Score  204.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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