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Tbio
C1GALT1C1
C1GALT1-specific chaperone 1

Protein Summary
Description
Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304661
  • ENSP00000304364
  • ENSG00000171155
  • ENST00000371313
  • ENSP00000360363

Symbol
  • COSMC
  • TNPS
  • COSMC
  • MST143
  • C1GALT2
  • HSPC067
  • C38H2-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.87
kinase perturbation
0.81
disease perturbation
0.79
tissue sample
0.72


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.22   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.22   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C1GALT1 specific chaperone 1
VGNC:1404
465837
Macaque
C1GALT1 specific chaperone 1
696662
Mouse
MGI:1913493
59048
Rat
RGD:1311230
302499
Dog
C1GALT1 specific chaperone 1
VGNC:38575
100685864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C1GALT1 specific chaperone 1
Macaque
C1GALT1 specific chaperone 1
Mouse
Rat
Dog
C1GALT1 specific chaperone 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96EU7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) (R-HSA-5083632)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Protein-Protein Interactions (101)
1 – 10 of 101
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
p_int:  0.997098763
p_ni:  0.002901237
Score:  0.635
Data Source:  BioPlex,STRINGDB
IL17F
Tbio
Novelty:  0.00223549
p_int:  0.994814556
p_ni:  0.005185444
Data Source:  BioPlex
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
p_int:  0.984693758
p_ni:  0.015301277
p_wrong:  0.000004965
Score:  0.183
Data Source:  BioPlex,STRINGDB
TOR1A
Tbio
Novelty:  0.00056274
p_int:  0.943258637
p_ni:  0.056741357
p_wrong:  6e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.84148308
p_ni:  0.158516916
p_wrong:  4e-9
Data Source:  BioPlex
ADPGK
Tbio
Family:  Kinase
Novelty:  0.0552414
p_int:  0.827959019
p_ni:  0.172040874
p_wrong:  1.07e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
ST3GAL4
Tbio
Family:  Enzyme
Novelty:  0.00419433
p_int:  0.781958383
p_ni:  0.218040874
p_wrong:  7.43e-7
Score:  0.605
Data Source:  BioPlex,STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.770203716
p_ni:  0.22979628
p_wrong:  3e-9
Data Source:  BioPlex
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
Score:  0.972
Data Source:  STRINGDB
ST6GALNAC1
Tbio
Family:  Enzyme
Novelty:  0.00453853
Score:  0.969
Data Source:  STRINGDB
Publication Statistics
PubMed Score  92.22

PubMed score by year
PubTator Score  54.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer