C1GALT1C1
C1GALT1-specific chaperone 1
Protein Summary
Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009]
- ENST00000304661
- ENSP00000304364
- ENSG00000171155
- ENST00000371313
- ENSP00000360363
- COSMC
- TNPS
- COSMC
- MST143
- C1GALT2
- HSPC067
- C38H2-L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
histone modification site profile | 0.87 | ||
kinase perturbation | 0.81 | ||
disease perturbation | 0.79 | ||
tissue sample | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.22 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 70 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.22 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 70 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
B3GNT2
Family: Enzyme
Novelty: 0.02724566
p_int: 0.997098763
p_ni: 0.002901237
Score: 0.635
Data Source: BioPlex,STRINGDB
SLC39A8
Family: Transporter
Novelty: 0.00923197
p_int: 0.984693758
p_ni: 0.015301277
p_wrong: 0.000004965
Score: 0.183
Data Source: BioPlex,STRINGDB
TOR1A
Novelty: 0.00056274
p_int: 0.943258637
p_ni: 0.056741357
p_wrong: 6e-9
Score: 0.23
Data Source: BioPlex,STRINGDB
HTR3A
Family: IC
Novelty: 0.00217443
p_int: 0.84148308
p_ni: 0.158516916
p_wrong: 4e-9
Data Source: BioPlex
ADPGK
Family: Kinase
Novelty: 0.0552414
p_int: 0.827959019
p_ni: 0.172040874
p_wrong: 1.07e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
ST3GAL4
Family: Enzyme
Novelty: 0.00419433
p_int: 0.781958383
p_ni: 0.218040874
p_wrong: 7.43e-7
Score: 0.605
Data Source: BioPlex,STRINGDB
SLC39A5
Family: Transporter
Novelty: 0.05205571
p_int: 0.770203716
p_ni: 0.22979628
p_wrong: 3e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (10)
Reactome (8)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | C1GALT1 specific chaperone 1 | VGNC:1404 | 465837 | |||||
Macaque | C1GALT1 specific chaperone 1 | 696662 | ||||||
Mouse | MGI:1913493 | 59048 | ||||||
Rat | RGD:1311230 | 302499 | ||||||
Dog | C1GALT1 specific chaperone 1 | VGNC:38575 | 100685864 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | C1GALT1 specific chaperone 1 | |||||
Macaque | C1GALT1 specific chaperone 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | C1GALT1 specific chaperone 1 | |||||
Publication Statistics
PubMed Score 92.22
PubMed score by year
PubTator Score 54.40
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (32)
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