Tdark TVP23C Golgi apparatus membrane protein TVP23 homolog C

Protein Summary

Description

This locus represents naturally occurring readthrough transcription between the neighboring TVP23C (trans-golgi network vesicle protein 23 homolog) and CDRT4 (CMT1A duplicated region transcript 4) genes on chromosome 17. Alternative splicing results in multiple transcript variants, one of which encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to frameshifts relative to the downstream gene. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q96ET8
• Q3LIC7

Gene Name

• TVP23C

Ensembl ID

• ENST00000225576
• ENSP00000225576
• ENSG00000175106
• ENST00000518321
• ENSP00000464052

Symbol

• FAM18B2
• TVP23C
• FAM18B2
• FAM18B2-CDRT4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.69
histone modification site profile	0.61
tissue	0.58
cell line	0.5
cell type or tissue	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0