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Tbio
SGF29
SAGA-associated factor 29

Protein Summary
Description
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317058
  • ENSP00000316114
  • ENSG00000176476

Symbol
  • CCDC101
  • STAF36
  • TDRD29
  • CCDC101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.5   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.5   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
4
1
7.3
96.1
1
1
0
1.1
48.8
refractive error measurement
1
1
1
48.4
platelet count
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
7.3
96.1
0
1.1
48.8
refractive error measurement
1
48.4
platelet count
1
25.4
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Protein-Protein Interactions (144)
1 – 10 of 144
TADA3
Tbio
Novelty: 0.01743814
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
TADA2B
Tbio
Family: TF
Novelty: 0.06387677
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
MBIP
Tbio
Novelty: 0.05807454
p_int: 0.999999992
p_ni: 8e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.999999388
p_ni: 6.12e-7
Data Source: BioPlex
ITPRID2
Tbio
Novelty: 0.07923791
p_int: 0.999998058
p_ni: 0.000001942
Data Source: BioPlex
RABGAP1L
Tbio
Family: Enzyme
Novelty: 0.2377644
p_int: 0.999997807
p_ni: 0.000002193
Data Source: BioPlex
RAB11FIP5
Tbio
Novelty: 0.0264203
p_int: 0.999997423
p_ni: 0.000002577
Data Source: BioPlex
TADA2A
Tbio
Family: TF
Novelty: 0.07665459
p_int: 0.999997186
p_ni: 0.000002796
p_wrong: 1.8e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
KAT2B
Tchem
Family: Epigenetic
Novelty: 0.00172126
p_int: 0.999995361
p_ni: 0.000004639
Score: 0.997
Data Source: BioPlex,STRINGDB
C16orf45
Tbio
Novelty: 0.00913059
p_int: 0.99999494
p_ni: 0.00000506
Data Source: BioPlex
Publication Statistics
PubMed Score  20.50

PubMed score by year
PubTator Score  6.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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