You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RNF125
E3 ubiquitin-protein ligase RNF125

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intrac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217740
  • ENSP00000217740
  • ENSG00000101695

Symbol
  • TNORS
  • TRAC1
  • TRAC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
transcription factor binding site profile
0.79
microRNA
0.75
cell type or tissue
0.74
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.88   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.88   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.974
Data Source:  STRINGDB
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
Score:  0.971
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.964
Data Source:  STRINGDB
UBE2L6
Tbio
Novelty:  0.03471633
Score:  0.958
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.951
Data Source:  Reactome,STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.939
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.918
Data Source:  STRINGDB
NPLOC4
Tbio
Novelty:  0.01690434
Score:  0.909
Data Source:  STRINGDB
UFD1
Tbio
Novelty:  0.01230296
Score:  0.904
Data Source:  STRINGDB
SIKE1
Tbio
Novelty:  0.14549184
Score:  0.733
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (100)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Negative regulators of DDX58/IFIH1 signaling
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Negative regulators of DDX58/IFIH1 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914914
67664
Rat
RGD:1306757
361296
Dog
ring finger protein 125
VGNC:45627
490498
Horse
ring finger protein 125
VGNC:22431
100052335
Cow
ring finger protein 125
VGNC:34017
519541
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ring finger protein 125
Horse
ring finger protein 125
Cow
ring finger protein 125
Publication Statistics
PubMed Score 11.88
PubMed score by year
PubTator Score 11.75
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title