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Tbio
SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

Protein Summary
Description
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381007
  • ENSP00000370395
  • ENSG00000197860

Symbol
  • SGT2
  • SGT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
microRNA
0.8
kinase perturbation
0.71
protein domain
0.58
transcription factor perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.12   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.12   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
1
1
0
8.2
66.8
daytime rest measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
0
8.2
66.8
daytime rest measurement
1
28.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small glutamine rich tetratricopeptide repeat containing beta
VGNC:7152
471528
Macaque
small glutamine rich tetratricopeptide repeat containing beta
696763
Mouse
MGI:2444615
218544
Rat
RGD:727976
294708
Dog
small glutamine rich tetratricopeptide repeat containing beta
VGNC:46108
478080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small glutamine rich tetratricopeptide repeat containing beta
Macaque
small glutamine rich tetratricopeptide repeat containing beta
Mouse
Rat
Dog
small glutamine rich tetratricopeptide repeat containing beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96EQ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (61)
1 – 10 of 61
ASNA1
Tbio
Family:  Enzyme
Novelty:  0.01260233
Score:  0.766
Data Source:  STRINGDB
GET4
Tbio
Novelty:  0.03516005
Score:  0.731
Data Source:  STRINGDB
UBL4A
Tbio
Novelty:  0.01278608
Score:  0.702
Data Source:  STRINGDB
FAM102A
Tdark
Novelty:  0.32284443
Score:  0.688
Data Source:  STRINGDB
FAM102B
Tdark
Novelty:  1.44024802
Score:  0.637
Data Source:  STRINGDB
CLPB
Tbio
Family:  Enzyme
Novelty:  0.00209789
Score:  0.634
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.623
Data Source:  STRINGDB
WRB
Tbio
Novelty:  0.01267171
Score:  0.593
Data Source:  STRINGDB
SHISAL2B
Tdark
Novelty:  7.97175866
Score:  0.591
Data Source:  STRINGDB
SREK1IP1
Tdark
Novelty:  1.39429464
Score:  0.572
Data Source:  STRINGDB
Publication Statistics
PubMed Score  38.12

PubMed score by year
PubTator Score  7.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer