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Tbio
CHFR
E3 ubiquitin-protein ligase CHFR

Protein Summary
Description
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266880
  • ENSP00000266880
  • ENSG00000072609
  • ENST00000432561
  • ENSP00000392395
  • ENST00000443047
  • ENSP00000416431
  • ENST00000450056
  • ENSP00000398735

Symbol
  • RNF196
  • RNF116
  • RNF196
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.94
histone modification site profile
0.89
disease perturbation
0.83
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.87   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.87   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Protein-Protein Interactions (84)
1 – 10 of 84
DTX3
Tbio
Family: Enzyme
Novelty: 0.06810215
p_int: 0.999999631
p_ni: 1.27e-7
p_wrong: 2.42e-7
Score: 0.529
Data Source: BioPlex,STRINGDB
UBE2W
Tbio
Novelty: 0.07925276
p_int: 0.999956578
p_ni: 2.1e-8
p_wrong: 0.000043401
Score: 0.269
Data Source: BioPlex,STRINGDB
C5orf24
Tdark
Novelty: 10
p_int: 0.999834935
p_ni: 1.79e-7
p_wrong: 0.000164887
Score: 0.206
Data Source: BioPlex,STRINGDB
APLF
Tbio
Novelty: 0.01671154
Score: 0.913
Data Source: STRINGDB
UBE2G2
Tbio
Novelty: 0.05545031
Score: 0.756
Data Source: STRINGDB
HLTF
Tbio
Family: Enzyme
Novelty: 0.01410809
Score: 0.723
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.72
Data Source: STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.00069833
Score: 0.701
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00071387
Score: 0.695
Data Source: STRINGDB
RASSF1
Tbio
Novelty: 0.00155893
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  110.87

PubMed score by year
PubTator Score  99.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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