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Tbio
RNF31
E3 ubiquitin-protein ligase RNF31

Protein Summary
Description
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other compo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324103
  • ENSP00000315112
  • ENSG00000092098
  • ENST00000559275
  • ENSP00000453574
  • ENST00000642631
  • ENSP00000494011
  • ENSG00000285152
  • ENST00000647495
  • ENSP00000496609

Symbol
  • ZIBRA
  • HOIP
  • Paul
  • ZIBRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.96
kinase perturbation
0.66
virus
0.66
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.88   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.88   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (503)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Regulation of TNFR1 signaling
Reactome
Signal Transduction
Reactome
TNF signaling
Reactome
TNFR1-induced NFkappaB signaling pathway
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Regulation of TNFR1 signaling
Signal Transduction
TNF signaling
TNFR1-induced NFkappaB signaling pathway
Protein-Protein Interactions (122)
1 – 10 of 122
SHARPIN
Tbio
Novelty: 0.02349893
p_int: 0.9999998
p_ni: 2e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LMO2
Tbio
Novelty: 0.00508219
p_int: 0.999998951
p_ni: 0.000001049
Data Source: BioPlex
LIPF
Tclin
Family: Enzyme
Novelty: 0.02292639
p_int: 0.999997798
p_ni: 0.000002202
Score: 0.571
Data Source: BioPlex,STRINGDB
RBCK1
Tbio
Novelty: 0.02344672
p_int: 0.999993431
p_ni: 6.8e-8
p_wrong: 0.000006501
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LTBR
Tbio
Novelty: 0.00438925
p_int: 0.999983409
p_ni: 0.000016591
Score: 0.156
Data Source: BioPlex,STRINGDB
CARTPT
Tbio
Novelty: 0.00031238
p_int: 0.999972281
p_ni: 0.000027718
p_wrong: 1e-9
Data Source: BioPlex
LDLRAD4
Tbio
Novelty: 0.02672907
p_int: 0.999386072
p_ni: 0.000613926
p_wrong: 2e-9
Data Source: BioPlex
RABGEF1
Tbio
Novelty: 0.03493884
p_int: 0.998720371
p_ni: 0.001279628
p_wrong: 1e-9
Score: 0.35
Data Source: BioPlex,STRINGDB
FKBPL
Tbio
Novelty: 0.03080376
p_int: 0.996798311
p_ni: 0.00319174
p_wrong: 0.000009949
Score: 0.42
Data Source: BioPlex,STRINGDB
SNTG2
Tbio
Novelty: 0.02799688
p_int: 0.996494659
p_ni: 0.003036264
p_wrong: 0.000469077
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  68.88

PubMed score by year
PubTator Score  35.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer