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Tbio
RNF31
E3 ubiquitin-protein ligase RNF31

Protein Summary
Description
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other compo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324103
  • ENSP00000315112
  • ENSG00000092098
  • ENST00000559275
  • ENSP00000453574
  • ENST00000642631
  • ENSP00000494011
  • ENSG00000285152
  • ENST00000647495
  • ENSP00000496609

Symbol
  • ZIBRA
  • HOIP
  • Paul
  • ZIBRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.96
kinase perturbation
0.66
virus
0.66
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.95   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.95   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.9999998
p_ni:  2e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999998951
p_ni:  0.000001049
Data Source:  BioPlex
LIPF
Tclin
Family:  Enzyme
Novelty:  0.03073254
p_int:  0.999997798
p_ni:  0.000002202
Score:  0.571
Data Source:  BioPlex,STRINGDB
RBCK1
Tbio
Novelty:  0.02760333
p_int:  0.999993431
p_ni:  6.8e-8
p_wrong:  0.000006501
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999983409
p_ni:  0.000016591
Score:  0.156
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.999972281
p_ni:  0.000027718
p_wrong:  1e-9
Data Source:  BioPlex
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999386072
p_ni:  0.000613926
p_wrong:  2e-9
Data Source:  BioPlex
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.998720371
p_ni:  0.001279628
p_wrong:  1e-9
Score:  0.35
Data Source:  BioPlex,STRINGDB
FKBPL
Tbio
Novelty:  0.02054842
p_int:  0.996798311
p_ni:  0.00319174
p_wrong:  0.000009949
Score:  0.42
Data Source:  BioPlex,STRINGDB
SNTG2
Tbio
Novelty:  0.04056715
p_int:  0.996494659
p_ni:  0.003036264
p_wrong:  0.000469077
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (503)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Regulation of TNFR1 signaling
Reactome
Signal Transduction
Reactome
TNF signaling
Reactome
TNFR1-induced NFkappaB signaling pathway
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Regulation of TNFR1 signaling
Signal Transduction
TNF signaling
TNFR1-induced NFkappaB signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 31
VGNC:12523
452810
Mouse
MGI:1934704
268749
Rat
RGD:1305513
364386
Dog
ring finger protein 31
480259
Cow
ring finger protein 31
509856
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 31
Mouse
Rat
Dog
ring finger protein 31
Cow
ring finger protein 31
Publication Statistics
PubMed Score 93.95
PubMed score by year
PubTator Score 35.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title