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Tbio
MOCOS
Molybdenum cofactor sulfurase

Protein Summary
Description
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime. This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261326
  • ENSP00000261326
  • ENSG00000075643

Symbol
  • MCS
  • MOS
  • HMCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.97
histone modification site profile
0.86
disease perturbation
0.74
gene perturbation
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
HSD17B8
Tbio
Family:  Enzyme
Novelty:  0.00915958
p_int:  0.999999558
p_ni:  4.41e-7
p_wrong:  1e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
PARVA
Tbio
Novelty:  0.02736601
p_int:  0.999984208
p_ni:  0.000015776
p_wrong:  1.5e-8
Score:  0.303
Data Source:  BioPlex,STRINGDB
HDAC7
Tclin
Family:  Epigenetic
Novelty:  0.00600484
p_int:  0.999952218
p_ni:  0.000047782
Data Source:  BioPlex
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
p_int:  0.999906286
p_ni:  0.000093713
Data Source:  BioPlex
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.999870331
p_ni:  0.000129669
Data Source:  BioPlex
IFIT1B
Tdark
Novelty:  0.29249041
p_int:  0.999644651
p_ni:  0.000355327
p_wrong:  2.3e-8
Score:  0.21
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.997952585
p_ni:  0.002047357
p_wrong:  5.8e-8
Data Source:  BioPlex
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.99253642
p_ni:  0.007463548
p_wrong:  3.2e-8
Data Source:  BioPlex
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
p_int:  0.990436916
p_ni:  0.009563083
Score:  0.173
Data Source:  BioPlex,STRINGDB
PLAU
Tchem
Family:  Enzyme
Novelty:  0.0005322
p_int:  0.976869943
p_ni:  0.02312786
p_wrong:  0.000002197
Score:  0.378
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Molybdenum cofactor biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Molybdenum cofactor biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
15.8
1
1
0
1.3
15.8
survival time
1
1
0
1.3
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
15.8
0
1.3
15.8
survival time
0
1.3
15.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
molybdenum cofactor sulfurase
VGNC:5186
455379
Macaque
molybdenum cofactor sulfurase
715633
Mouse
MGI:1915841
68591
Rat
RGD:1308496
361300
Dog
molybdenum cofactor sulfurase
VGNC:43305
490482
Species
Name
OMA
EggNOG
Inparanoid
Chimp
molybdenum cofactor sulfurase
Macaque
molybdenum cofactor sulfurase
Mouse
Rat
Dog
molybdenum cofactor sulfurase
Publication Statistics
PubMed Score 20.88
PubMed score by year
PubTator Score 12.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title