FAM120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma
Protein Summary
Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).
- ENST00000476287
- ENSP00000417970
- ENSG00000112584
- ENST00000616072
- ENSP00000482544
- ENSG00000275333
- ENST00000617082
- ENSP00000481344
- ENST00000625626
- ENSP00000485793
- CCPG
- KIAA1838
- CCPG
- PGCC1
- KIAA1838
- dJ894D12.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
kinase perturbation | 0.88 | ||
histone modification site profile | 0.78 | ||
transcription factor binding site profile | 0.74 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.62 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.62 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (93)
FLCN
Novelty: 0.0022007
p_int: 0.999993764
p_ni: 0.000006236
Score: 0.239
Data Source: BioPlex,STRINGDB
COP1
Family: Enzyme
Novelty: 0.10908534
p_int: 0.999992807
p_ni: 0.000007193
Score: 0.183
Data Source: BioPlex,STRINGDB
SPANXN4
Novelty: 1.91062423
p_int: 0.99990747
p_ni: 0.000092524
p_wrong: 6e-9
Data Source: BioPlex
IMPDH1
Family: Enzyme
Novelty: 0.00758575
p_int: 0.997728281
p_ni: 0.002266478
p_wrong: 0.000005241
Data Source: BioPlex
DOK2
Novelty: 0.02651438
p_int: 0.992734616
p_ni: 0.007262228
p_wrong: 0.000003156
Score: 0.187
Data Source: BioPlex,STRINGDB
GSTM3
Family: Enzyme
Novelty: 0.0078192
p_int: 0.908322482
p_ni: 0.00870225
p_wrong: 0.082975269
Score: 0.237
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (6)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PPARA activates gene expression | ||||
Reactome | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Metabolism | ||||
Metabolism of lipids | ||||
PPARA activates gene expression | ||||
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte count | 1 | 1 | 1 | 72.6 | |||||
platelet crit | 1 | 1 | 1 | 72.2 | |||||
lymphocyte count | 2 | 2 | 2 | 72.1 | |||||
daytime rest measurement | 1 | 1 | 1 | 51.4 | |||||
hematocrit | 2 | 2 | 2 | 48.3 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte count | 1 | 72.6 | |||||
platelet crit | 1 | 72.2 | |||||
lymphocyte count | 2 | 72.1 | |||||
daytime rest measurement | 1 | 51.4 | |||||
hematocrit | 2 | 48.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 120B | VGNC:11071 | 465122 | |||||
Macaque | family with sequence similarity 120B | 696010 | ||||||
Mouse | MGI:1914794 | 67544 | ||||||
Rat | RGD:1310304 | 308218 | ||||||
Dog | family with sequence similarity 120B | 612641 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 120B | |||||
Macaque | family with sequence similarity 120B | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 120B | |||||
Publication Statistics
PubMed Score 10.62
PubMed score by year
PubTator Score 1.44
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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