You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAM120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Protein Summary
Description
Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000476287
  • ENSP00000417970
  • ENSG00000112584
  • ENST00000616072
  • ENSP00000482544
  • ENSG00000275333
  • ENST00000617082
  • ENSP00000481344
  • ENST00000625626
  • ENSP00000485793

Symbol
  • CCPG
  • KIAA1838
  • CCPG
  • PGCC1
  • KIAA1838
  • dJ894D12.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
kinase perturbation
0.88
histone modification site profile
0.78
transcription factor binding site profile
0.74
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.999993764
p_ni:  0.000006236
Score:  0.239
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.999992807
p_ni:  0.000007193
Score:  0.183
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.99990747
p_ni:  0.000092524
p_wrong:  6e-9
Data Source:  BioPlex
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.999891688
p_ni:  0.000108312
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.997728281
p_ni:  0.002266478
p_wrong:  0.000005241
Data Source:  BioPlex
DOK2
Tbio
Novelty:  0.02651438
p_int:  0.992734616
p_ni:  0.007262228
p_wrong:  0.000003156
Score:  0.187
Data Source:  BioPlex,STRINGDB
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
p_int:  0.908322482
p_ni:  0.00870225
p_wrong:  0.082975269
Score:  0.237
Data Source:  BioPlex,STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.959
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.939
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
72.6
platelet crit
1
1
1
72.2
lymphocyte count
2
2
2
72.1
daytime rest measurement
1
1
1
51.4
hematocrit
2
2
2
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
72.6
platelet crit
1
72.2
lymphocyte count
2
72.1
daytime rest measurement
1
51.4
hematocrit
2
48.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 120B
VGNC:11071
465122
Macaque
family with sequence similarity 120B
696010
Mouse
MGI:1914794
67544
Rat
RGD:1310304
308218
Dog
family with sequence similarity 120B
612641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 120B
Macaque
family with sequence similarity 120B
Mouse
Rat
Dog
family with sequence similarity 120B
Publication Statistics
PubMed Score 10.62
PubMed score by year
PubTator Score 1.44
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title