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Tbio
KIF1BP
KIF1-binding protein

Protein Summary
Description
Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating transport of the mitochondria. Mutations in this gene are associated with Goldberg-Shprintzen megacolon syndrome. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361983
  • ENSP00000354848
  • ENSG00000198954

Symbol
  • KBP
  • KIAA1279
  • KBP
  • TTC20
  • KIAA1279
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
interacting protein
0.83
kinase perturbation
0.81
transcription factor binding site profile
0.71
tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.94   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.94   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
4
4
87.7
comparative body size at age 10, self-reported
1
1
1
42.3
eosinophil percentage of leukocytes
1
1
1
12.3
eosinophil count
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
4
87.7
comparative body size at age 10, self-reported
1
42.3
eosinophil percentage of leukocytes
1
12.3
eosinophil count
1
7.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIF1 binding protein
VGNC:4722
450502
Macaque
KIF1 binding protein
717469
Mouse
MGI:1919570
72320
Rat
RGD:1593126
606294
Dog
KIF1 binding protein
VGNC:42392
479232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIF1 binding protein
Macaque
KIF1 binding protein
Mouse
Rat
Dog
KIF1 binding protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96EK5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (46)
1 – 10 of 46
KIF18A
Tbio
Novelty:  0.02071108
p_int:  0.999999994
p_ni:  5e-9
p_wrong:  1e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
KIF16B
Tbio
Novelty:  0.06703876
p_int:  0.999999993
p_ni:  7e-9
Score:  0.34
Data Source:  BioPlex,STRINGDB
KIF15
Tchem
Novelty:  0.01328603
p_int:  0.99999999
p_wrong:  9e-9
Score:  0.331
Data Source:  BioPlex,STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.99999991
p_ni:  9e-8
Score:  0.588
Data Source:  BioPlex,STRINGDB
KIF13A
Tbio
Novelty:  0.04988003
p_int:  0.999999894
p_ni:  1.05e-7
p_wrong:  1e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
KIF18B
Tbio
Novelty:  0.06496349
p_int:  0.999999746
p_ni:  2.53e-7
p_wrong:  2e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
KIF1A
Tbio
Novelty:  0.00505209
p_int:  0.999999294
p_ni:  7.06e-7
Score:  0.677
Data Source:  BioPlex,STRINGDB
KIF14
Tbio
Novelty:  0.02313641
p_int:  0.999999093
p_ni:  9.07e-7
Score:  0.705
Data Source:  BioPlex,STRINGDB
KIF1B
Tbio
Novelty:  0.00984332
p_int:  0.999997761
p_ni:  0.000002239
Score:  0.614
Data Source:  BioPlex,STRINGDB
KIF3C
Tbio
Novelty:  0.0512445
p_int:  0.999990747
p_ni:  0.000009197
p_wrong:  5.6e-8
Score:  0.745
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  21.94

PubMed score by year
PubTator Score  148.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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