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Tbio
MALSU1
Mitochondrial assembly of ribosomal large subunit protein 1

Protein Summary
Description
Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000466681
  • ENSP00000419370
  • ENSG00000156928

Symbol
  • C7orf30
  • mtRsfA
  • C7orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
transcription factor perturbation
0.84
histone modification site profile
0.8
kinase perturbation
0.76
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.996771195
p_ni:  0.003228805
p_wrong:  1e-9
Score:  0.939
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.994268581
p_ni:  0.005731219
p_wrong:  2e-7
Score:  0.816
Data Source:  BioPlex,STRINGDB
MRPL41
Tbio
Novelty:  0.04024303
p_int:  0.991344144
p_ni:  0.008636138
p_wrong:  0.000019718
Score:  0.938
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.987993981
p_ni:  0.012006019
Score:  0.927
Data Source:  BioPlex,STRINGDB
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.987840736
p_ni:  0.012159261
p_wrong:  3e-9
Score:  0.839
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.986691453
p_ni:  0.013308528
p_wrong:  1.9e-8
Score:  0.938
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.985598067
p_ni:  0.014401933
Score:  0.95
Data Source:  BioPlex,STRINGDB
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.983825651
p_ni:  0.016174349
Score:  0.832
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.983181211
p_ni:  0.016818786
p_wrong:  3e-9
Score:  0.843
Data Source:  BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty:  0.03765684
p_int:  0.979054745
p_ni:  0.020945253
p_wrong:  2e-9
Score:  0.881
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
69.8
C-reactive protein measurement
1
1
1
54.4
1
1
1
50.6
1
1
0
3.9
36.9
BMI-adjusted hip circumference
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
69.8
C-reactive protein measurement
1
54.4
1
50.6
0
3.9
36.9
BMI-adjusted hip circumference
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial assembly of ribosomal large subunit 1
VGNC:14047
744284
Macaque
mitochondrial assembly of ribosomal large subunit 1
704884
Mouse
MGI:1922843
75593
Rat
RGD:1306936
297082
Dog
mitochondrial assembly of ribosomal large subunit 1
VGNC:42935
611116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial assembly of ribosomal large subunit 1
Macaque
mitochondrial assembly of ribosomal large subunit 1
Mouse
Rat
Dog
mitochondrial assembly of ribosomal large subunit 1
Publication Statistics
PubMed Score 5.05
PubMed score by year
PubTator Score 3.70
PubTator score by year
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Related Publications
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PMID
Year
Title