You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MALSU1
Mitochondrial assembly of ribosomal large subunit protein 1

Protein Summary
Description
Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000466681
  • ENSP00000419370
  • ENSG00000156928

Symbol
  • C7orf30
  • mtRsfA
  • C7orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
transcription factor perturbation
0.84
histone modification site profile
0.8
kinase perturbation
0.76
small molecule perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial assembly of ribosomal large subunit 1
VGNC:14047
744284
Macaque
mitochondrial assembly of ribosomal large subunit 1
704884
Mouse
MGI:1922843
75593
Rat
RGD:1306936
297082
Dog
mitochondrial assembly of ribosomal large subunit 1
VGNC:42935
611116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial assembly of ribosomal large subunit 1
Macaque
mitochondrial assembly of ribosomal large subunit 1
Mouse
Rat
Dog
mitochondrial assembly of ribosomal large subunit 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96EH3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (139)
1 – 10 of 139
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.996771195
p_ni: 0.003228805
p_wrong: 1e-9
Score: 0.939
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.994268581
p_ni: 0.005731219
p_wrong: 2e-7
Score: 0.816
Data Source: BioPlex,STRINGDB
MRPL41
Tbio
Novelty: 0.04024303
p_int: 0.991344144
p_ni: 0.008636138
p_wrong: 0.000019718
Score: 0.938
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.987993981
p_ni: 0.012006019
Score: 0.927
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.987840736
p_ni: 0.012159261
p_wrong: 3e-9
Score: 0.839
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.986691453
p_ni: 0.013308528
p_wrong: 1.9e-8
Score: 0.938
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.985598067
p_ni: 0.014401933
Score: 0.95
Data Source: BioPlex,STRINGDB
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.983825651
p_ni: 0.016174349
Score: 0.832
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.983181211
p_ni: 0.016818786
p_wrong: 3e-9
Score: 0.843
Data Source: BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty: 0.03765684
p_int: 0.979054745
p_ni: 0.020945253
p_wrong: 2e-9
Score: 0.881
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.88

PubMed score by year
PubTator Score  3.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer