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Tbio
FBXO17
F-box only protein 17

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins. This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292852
  • ENSP00000292852
  • ENSG00000269190
  • ENST00000595329
  • ENSP00000470361
  • ENST00000634982
  • ENSP00000488997
  • ENSG00000282954
  • ENST00000635115
  • ENSP00000489327

Symbol
  • FBG4
  • FBX17
  • FBX26
  • FBXO26
  • FBG4
  • FBX26
  • Fbx17
  • FBXO26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor
0.66
cellular component
0.61
tissue sample
0.59
transcription factor binding site profile
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
1
1
81.1
SIR2-like protein 2 measurement
1
1
1
81.1
serum gamma-glutamyl transferase measurement
1
1
1
50.6
serum gamma-glutamyl transferase measurement
1
1
1
50.6
diastolic blood pressure
1
1
1
40.7
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
81.1
SIR2-like protein 2 measurement
1
81.1
serum gamma-glutamyl transferase measurement
1
50.6
serum gamma-glutamyl transferase measurement
1
50.6
diastolic blood pressure
1
40.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1354707
50760
Rat
RGD:1308308
292757
Dog
F-box protein 17
VGNC:40764
484516
Cow
F-box protein 17
VGNC:28895
510874
Anole lizard
F-box only protein 17
100567035
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
F-box protein 17
Cow
F-box protein 17
Anole lizard
F-box only protein 17
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96EF6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (331)
1 – 10 of 331
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.999998555
p_ni:  2.61e-7
p_wrong:  0.000001184
Data Source:  BioPlex
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999993007
p_ni:  0.000006993
Score:  0.965
Data Source:  BioPlex,STRINGDB
FBXW2
Tbio
Novelty:  0.01492058
p_int:  0.999965816
p_ni:  0.000034181
p_wrong:  3e-9
Score:  0.946
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.996757718
p_ni:  0.003242282
Score:  0.991
Data Source:  BioPlex,STRINGDB
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.994964723
p_ni:  0.004970424
p_wrong:  0.000064853
Data Source:  BioPlex
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.99457516
p_ni:  0.005424834
p_wrong:  6e-9
Score:  0.969
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.990966909
p_ni:  0.009033091
Data Source:  BioPlex
SARS2
Tbio
Family:  Enzyme
Novelty:  0.00772323
p_int:  0.966440647
p_ni:  0.033559353
Score:  0.33
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.947804486
p_ni:  0.052195514
Score:  0.977
Data Source:  BioPlex,STRINGDB
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
p_int:  0.946167593
p_ni:  0.053832407
Score:  0.186
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.85

PubMed score by year
PubTator Score  3.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer