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Tbio
MTMR8
Myotubularin-related protein 8

Protein Summary
Description
Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374852
  • ENSP00000363985
  • ENSG00000102043
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
histone modification site profile
0.58
cell line
0.51
tissue
0.51
microRNA
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
MTMR9
Tbio
Novelty:  0.09702778
p_int:  0.999996495
p_ni:  0.000003501
p_wrong:  4e-9
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
MTMR7
Tbio
Family:  Enzyme
Novelty:  0.1707096
p_int:  0.999986938
p_ni:  1.67e-7
p_wrong:  0.000012895
Score:  0.828
Data Source:  BioPlex,STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.99993359
p_ni:  0.00006635
p_wrong:  6e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
ARL11
Tbio
Family:  Enzyme
Novelty:  0.04033783
p_int:  0.999874705
p_ni:  0.000113513
p_wrong:  0.000011781
Score:  0.265
Data Source:  BioPlex,STRINGDB
PIKFYVE
Tchem
Family:  Kinase
Novelty:  0.00441336
Score:  0.929
Data Source:  STRINGDB
CDIPT
Tbio
Family:  Enzyme
Novelty:  0.00560887
Score:  0.904
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.834
Data Source:  STRINGDB
SACM1L
Tbio
Family:  Enzyme
Novelty:  0.00499867
Score:  0.767
Data Source:  STRINGDB
PLCB4
Tbio
Family:  Enzyme
Novelty:  0.01840915
Score:  0.732
Data Source:  STRINGDB
PLCB1
Tbio
Family:  Enzyme
Novelty:  0.00269771
Score:  0.717
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (8)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 8
VGNC:2696
465670
Macaque
myotubularin related protein 8
708037
Horse
myotubularin related protein 8
VGNC:20430
100054675
Pig
myotubularin related protein 8
100514555
Chicken
myotubularin related protein 8
CGNC:5726
422312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 8
Macaque
myotubularin related protein 8
Horse
myotubularin related protein 8
Pig
myotubularin related protein 8
Chicken
myotubularin related protein 8
Publication Statistics
PubMed Score 3.62
PubMed score by year
PubTator Score 3.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title