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Tbio
SEH1L
Nucleoporin SEH1

Protein Summary
Description
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262124
  • ENSP00000262124
  • ENSG00000085415
  • ENST00000399892
  • ENSP00000382779

Symbol
  • SEC13L
  • SEH1
  • Seh1
  • SEH1A
  • SEH1B
  • SEC13L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
interacting protein
0.95
histone modification site profile
0.91
transcription factor binding site profile
0.88
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
65.5
intelligence
3
1
1
5.7
33
self reported educational attainment
2
1
1
5.8
26
heel bone mineral density
1
1
1
21.6
1
1
1
19.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
65.5
intelligence
1
5.7
33
self reported educational attainment
1
5.8
26
heel bone mineral density
1
21.6
1
19.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEH1 like nucleoporin
VGNC:5203
100613956
Mouse
MGI:1919374
72124
Horse
SEH1 like nucleoporin
VGNC:50969
100630847
Cow
SEH1 like nucleoporin
VGNC:34420
506509
Opossum
SEH1 like nucleoporin
103099906
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEH1 like nucleoporin
Mouse
Horse
SEH1 like nucleoporin
Cow
SEH1 like nucleoporin
Opossum
SEH1 like nucleoporin
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (83)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (131)
1 – 10 of 131
BGLAP
Tbio
Novelty: 0.00009678
p_int: 0.99912467
p_ni: 0.00087533
Data Source: BioPlex
NELL2
Tbio
Family: Enzyme
Novelty: 0.03760438
p_int: 0.996105941
p_ni: 0.003894059
Data Source: BioPlex
NUP43
Tbio
Novelty: 0.11571309
p_int: 0.993266491
p_ni: 0.006733509
Score: 0.995
Data Source: BioPlex,STRINGDB
PDGFD
Tbio
Novelty: 0.00799996
p_int: 0.964025233
p_ni: 0.035974767
Score: 0.175
Data Source: BioPlex,STRINGDB
CRYAB
Tbio
Novelty: 0.00464213
p_int: 0.962300723
p_ni: 0.037699277
Data Source: BioPlex
ADIPOQ
Tbio
Novelty: 0.00011196
p_int: 0.938956971
p_ni: 0.061043029
Data Source: BioPlex
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.93752943
p_ni: 0.06247057
Data Source: BioPlex
CXCL1
Tbio
Novelty: 0.00059123
p_int: 0.906294363
p_ni: 0.093705637
Data Source: BioPlex
CCDC102B
Tdark
Novelty: 0.28075569
p_int: 0.873809507
p_ni: 0.126190493
Data Source: BioPlex
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.846593191
p_ni: 0.153406809
Data Source: BioPlex
Publication Statistics
PubMed Score  23.75

PubMed score by year
PubTator Score  3.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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