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Tchem
SIRT1
NAD-dependent protein deacetylase sirtuin-1

Protein Summary
Description
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, Pu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000212015
  • ENSP00000212015
  • ENSG00000096717

Symbol
  • SIR2L1
  • SIR2
  • SIR2L1
  • SIR2alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
chemical
0.99
hub protein
0.92
gene perturbation
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6995.94   (req: < 5)
Gene RIFs: 974   (req: <= 3)
Antibodies: 1001   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6995.94   (req: >= 5)
Gene RIFs: 974   (req: > 3)
Antibodies: 1001   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 137
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 123
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1