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Tchem
SIRT1
NAD-dependent protein deacetylase sirtuin-1

Protein Summary
Description
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, Pu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000212015
  • ENSP00000212015
  • ENSG00000096717

Symbol
  • SIR2L1
  • SIR2
  • SIR2L1
  • SIR2alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
chemical
0.99
hub protein
0.92
gene perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5782.73   (req: < 5)
Gene RIFs: 974   (req: <= 3)
Antibodies: 1001   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5782.73   (req: >= 5)
Gene RIFs: 974   (req: > 3)
Antibodies: 1001   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 137
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
suramin
chemical structure image
Active Ligands (85)
1 – 10 of 85
CHEMBL3806268
chemical structure image
CHEMBL2338812
chemical structure image
CHEMBL2332053
chemical structure image
CHEMBL2338811
chemical structure image
CHEMBL3804834
chemical structure image
CHEMBL3805950
chemical structure image
CHEMBL3889954
chemical structure image
CHEMBL2338818
chemical structure image
CHEMBL3781645
chemical structure image
CHEMBL2338809
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sirtuin 1
VGNC:12502
107966703
Macaque
sirtuin 1
695682
Mouse
MGI:2135607
93759
Dog
sirtuin 1
VGNC:46183
489012
Horse
sirtuin 1
VGNC:51676
100072571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sirtuin 1
Macaque
sirtuin 1
Mouse
Dog
sirtuin 1
Horse
sirtuin 1
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (132)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Circadian Clock
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Circadian Clock
Epigenetic regulation of gene expression
Gene Ontology Terms (151)
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (702)
1 – 10 of 702
ZBTB38
Tbio
Family: TF
Novelty: 0.05048192
p_int: 0.999994366
p_ni: 0.000005634
Score: 0.164
Data Source: BioPlex,STRINGDB
TADA2B
Tbio
Family: TF
Novelty: 0.06387677
p_int: 0.999943713
p_ni: 0.000056287
Score: 0.262
Data Source: BioPlex,STRINGDB
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
p_int: 0.999934409
p_ni: 0.000065591
Score: 0.204
Data Source: BioPlex,STRINGDB
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.99991614
p_ni: 0.00008386
Score: 0.28
Data Source: BioPlex,STRINGDB
CDKL1
Tchem
Family: Kinase
Novelty: 0.110338
p_int: 0.998869104
p_ni: 0.001130896
Score: 0.447
Data Source: BioPlex,STRINGDB
SFRP4
Tbio
Novelty: 0.00174428
p_int: 0.998859276
p_ni: 0.001140724
Score: 0.2
Data Source: BioPlex,STRINGDB
ZNF514
Tdark
Family: TF
Novelty: 8.86800961
p_int: 0.998747015
p_ni: 0.001252985
Data Source: BioPlex
CERKL
Tbio
Family: Enzyme
Novelty: 0.04190552
p_int: 0.998605785
p_ni: 0.001394215
Score: 0.161
Data Source: BioPlex,STRINGDB
MTA1
Tbio
Family: TF
Novelty: 0.00464618
p_int: 0.998450778
p_ni: 0.001549222
Score: 0.83
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.998272673
p_ni: 0.001727327
Score: 0.98
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5782.73

PubMed score by year
PubTator Score  2618.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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