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Tbio
ELP4
Elongator complex protein 4

Protein Summary
Description
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379163
  • ENSP00000368461
  • ENSG00000109911
  • ENST00000640961
  • ENSP00000492152

Symbol
  • C11orf19
  • PAXNEB
  • AN
  • AN2
  • hELP4
  • PAXNEB
  • PAX6NEB
  • C11orf19
  • dJ68P15A.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.88
molecular function
0.84
disease perturbation
0.68
cell line
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.55   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.55   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  1
Data Source:  BioPlex
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
p_int:  0.999999933
p_ni:  6.7e-8
Score:  0.933
Data Source:  BioPlex,STRINGDB
ELP6
Tbio
Novelty:  0.01229878
p_int:  0.999994141
p_ni:  0.000005859
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
p_int:  0.999983564
p_ni:  0.000016436
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ELP5
Tbio
Novelty:  0.07212185
p_int:  0.996907857
p_ni:  0.000005999
p_wrong:  0.003086144
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.990029089
p_ni:  0.009970912
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.984719457
p_ni:  0.014403404
p_wrong:  0.000877139
Data Source:  BioPlex
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.978058578
p_ni:  0.021940683
p_wrong:  7.4e-7
Data Source:  BioPlex
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.936019673
p_ni:  0.063968257
p_wrong:  0.00001207
Data Source:  BioPlex
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.904564259
p_ni:  0.095435742
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
5
5
4
6.2
77
optic disc size measurement
1
1
1
76.9
wellbeing measurement
3
2
3
72.1
depressive symptom measurement
3
2
3
69.6
optic disc area measurement
3
3
4
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
6.2
77
optic disc size measurement
1
76.9
wellbeing measurement
3
72.1
depressive symptom measurement
3
69.6
optic disc area measurement
4
63.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongator acetyltransferase complex subunit 4
VGNC:11346
451103
Mouse
MGI:1925016
77766
Rat
Cow
elongator acetyltransferase complex subunit 4
VGNC:28457
614139
Pig
elongator acetyltransferase complex subunit 4
100514702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongator acetyltransferase complex subunit 4
Mouse
Rat
Cow
elongator acetyltransferase complex subunit 4
Pig
elongator acetyltransferase complex subunit 4
Publication Statistics
PubMed Score 25.55
PubMed score by year
PubTator Score 68.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title