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Tbio
SPDL1
Protein Spindly

Protein Summary
Description
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). This gene encodes a coiled-coil domain-containing protein that functions in mitot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265295
  • ENSP00000265295
  • ENSG00000040275

Symbol
  • CCDC99
  • CCDC99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
histone modification site profile
0.74
transcription factor binding site profile
0.63
transcription factor perturbation
0.54
cellular component
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.21   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.21   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999998719
p_ni:  0.000001281
Data Source:  BioPlex
GSTT2B
Tbio
Family:  Enzyme
Novelty:  0.02334158
p_int:  0.999998319
p_ni:  0.000001681
Score:  0.187
Data Source:  BioPlex,STRINGDB
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.999982229
p_ni:  0.000017771
Data Source:  BioPlex
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.999885965
p_ni:  0.000114035
Score:  0.912
Data Source:  BioPlex,STRINGDB
TXLNB
Tbio
Novelty:  0.12751933
p_int:  0.999741033
p_ni:  0.000258967
Score:  0.177
Data Source:  BioPlex,STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.997935741
p_ni:  0.002064253
p_wrong:  6e-9
Data Source:  BioPlex
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.997794984
p_ni:  0.002205007
p_wrong:  9e-9
Data Source:  BioPlex
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.996429686
p_ni:  0.00357026
p_wrong:  5.4e-8
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.995765595
p_ni:  0.004234393
p_wrong:  1.1e-8
Data Source:  BioPlex
THUMPD2
Tdark
Novelty:  0.66682546
p_int:  0.995631532
p_ni:  0.00436839
p_wrong:  7.8e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
74.5
self reported educational attainment
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
74.5
self reported educational attainment
1
5.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spindle apparatus coiled-coil protein 1
VGNC:4173
462255
Macaque
spindle apparatus coiled-coil protein 1
699624
Mouse
MGI:1917635
70385
Rat
RGD:1306908
303037
Dog
spindle apparatus coiled-coil protein 1
VGNC:46727
479295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spindle apparatus coiled-coil protein 1
Macaque
spindle apparatus coiled-coil protein 1
Mouse
Rat
Dog
spindle apparatus coiled-coil protein 1
Publication Statistics
PubMed Score 104.21
PubMed score by year
PubTator Score 9.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title