Tbio KLRG1 Killer cell lectin-like receptor subfamily G member 1

Protein Summary

Description

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]

Uniprot Accession IDs

• Q96E93
• B7ZAM2
• O43198
• O75613

Gene Name

• KLRG1

Ensembl ID

• ENST00000266551
• ENSP00000266551
• ENSG00000139187
• ENST00000356986
• ENSP00000349477

Symbol

• CLEC15A
• MAFA
• MAFAL
• 2F1
• MAFA
• MAFA-L
• CLEC15A
• MAFA-2F1
• MAFA-LIKE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.71
virus perturbation	0.68
gene perturbation	0.6
small molecule perturbation	0.56
cell type or tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.61   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 403   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.61   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0