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Tbio
OMA1
Metalloendopeptidase OMA1, mitochondrial

Protein Summary
Description
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371226
  • ENSP00000360270
  • ENSG00000162600

Symbol
  • MPRP1
  • DAB1
  • MPRP1
  • MPRP-1
  • YKR087C
  • ZMPOMA1
  • peptidase
  • 2010001O09Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
kinase perturbation
0.76
histone modification site profile
0.72
virus perturbation
0.68
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.3   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.3   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
p_int:  0.999987968
p_ni:  0.000012032
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.99957919
p_ni:  0.00042081
Data Source:  BioPlex
IFNA8
Tbio
Novelty:  0.0310922
p_int:  0.999501136
p_ni:  0.000498864
Score:  0.303
Data Source:  BioPlex,STRINGDB
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.996471986
p_ni:  0.003528014
Data Source:  BioPlex
TOR3A
Tbio
Novelty:  0.11588309
p_int:  0.995086706
p_ni:  0.004902081
p_wrong:  0.000011214
Score:  0.209
Data Source:  BioPlex,STRINGDB
TPP1
Tbio
Family:  Enzyme
Novelty:  0.00590008
p_int:  0.990018224
p_ni:  0.009981776
Score:  0.292
Data Source:  BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.984606278
p_ni:  0.015393722
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.981443289
p_ni:  0.018556318
p_wrong:  3.92e-7
Data Source:  BioPlex
CNPPD1
Tdark
Novelty:  1.33885532
p_int:  0.974547617
p_ni:  0.02545238
p_wrong:  3e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.959618002
p_ni:  0.039994047
p_wrong:  0.000387951
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Programmed Cell Death
Reactome
Regulation of Apoptosis
Name
Explore in Pharos
Explore in Source
Apoptosis
Programmed Cell Death
Regulation of Apoptosis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
17.8
biological sex
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
17.8
biological sex
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
OMA1 zinc metallopeptidase
716294
Mouse
MGI:1914263
67013
Rat
RGD:1304821
298282
Dog
OMA1 zinc metallopeptidase
VGNC:44121
489569
Horse
OMA1 zinc metallopeptidase
VGNC:21031
100067642
Species
Name
OMA
EggNOG
Inparanoid
Macaque
OMA1 zinc metallopeptidase
Mouse
Rat
Dog
OMA1 zinc metallopeptidase
Horse
OMA1 zinc metallopeptidase
Publication Statistics
PubMed Score 109.30
PubMed score by year
PubTator Score 18.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title