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Tbio
OMA1
Metalloendopeptidase OMA1, mitochondrial

Protein Summary
Description
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371226
  • ENSP00000360270
  • ENSG00000162600

Symbol
  • MPRP1
  • DAB1
  • MPRP1
  • MPRP-1
  • YKR087C
  • ZMPOMA1
  • peptidase
  • 2010001O09Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
kinase perturbation
0.76
histone modification site profile
0.72
virus perturbation
0.68
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.37   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.37   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0