Tbio MTERF3 Transcription termination factor 3, mitochondrial

Protein Summary

Description

Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).

Uniprot Accession IDs

• Q96E29
• B3KMG6
• G3V130
• Q9Y301

Gene Name

• MTERF3

Ensembl ID

• ENST00000287025
• ENSP00000287025
• ENSG00000156469
• ENST00000522822
• ENSP00000430138

Symbol

• MTERFD1
• CGI-12
• MTERFD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.69
histone modification site profile	0.67
transcription factor binding site profile	0.67
transcription factor	0.64
cell type or tissue	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0