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Tdark
MTERF3
Transcription termination factor 3, mitochondrial

Protein Summary
Description
Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287025
  • ENSP00000287025
  • ENSG00000156469
  • ENST00000522822
  • ENSP00000430138

Symbol
  • MTERFD1
  • CGI-12
  • MTERFD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
histone modification site profile
0.67
transcription factor binding site profile
0.67
transcription factor
0.64
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.49   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.49   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.999632161
p_ni:  0.000367839
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.995952481
p_ni:  0.004047519
Data Source:  BioPlex
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.995784995
p_ni:  0.004215005
Score:  0.347
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.994591334
p_ni:  0.005408666
Score:  0.53
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.992811711
p_ni:  0.007188289
Score:  0.186
Data Source:  BioPlex,STRINGDB
RBMX
Tbio
Novelty:  0.01705784
p_int:  0.981016527
p_ni:  0.018983473
Data Source:  BioPlex
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.980079494
p_ni:  0.019920506
Data Source:  BioPlex
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.979678521
p_ni:  0.020321479
Data Source:  BioPlex
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  0.976867752
p_ni:  0.023132248
Data Source:  BioPlex
DDX28
Tbio
Family:  Enzyme
Novelty:  0.16760542
p_int:  0.970896368
p_ni:  0.029103632
Score:  0.813
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitophagy
Reactome
Pink/Parkin Mediated Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitophagy
Pink/Parkin Mediated Mitophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left atrial function
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left atrial function
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial transcription termination factor 3
VGNC:840
464295
Macaque
mitochondrial transcription termination factor 3
701366
Mouse
MGI:1913660
66410
Rat
RGD:735158
299514
Dog
mitochondrial transcription termination factor 3
VGNC:43465
100684270
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial transcription termination factor 3
Macaque
mitochondrial transcription termination factor 3
Mouse
Rat
Dog
mitochondrial transcription termination factor 3
Publication Statistics
PubMed Score 12.49
PubMed score by year
PubTator Score 6.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title