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Tbio
RAB3C
Ras-related protein Rab-3C

Protein Summary
Description
Protein transport. Probably involved in vesicular traffic (By similarity). This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282878
  • ENSP00000282878
  • ENSG00000152932
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
histone modification site profile
0.75
gene perturbation
0.62
transcription factor perturbation
0.61
cellular component
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.51   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.51   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
43
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
43
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB3C, member RAS oncogene family
VGNC:13577
471537
Macaque
RAB3C, member RAS oncogene family
709039
Mouse
MGI:1914545
67295
Rat
RGD:620923
171058
Dog
RAB3C, member RAS oncogene family
VGNC:45284
608817
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB3C, member RAS oncogene family
Macaque
RAB3C, member RAS oncogene family
Mouse
Rat
Dog
RAB3C, member RAS oncogene family
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96E17-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (147)
1 – 10 of 147
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
RAB35
Tbio
Family: Enzyme
Novelty: 0.01514601
Score: 0.974
Data Source: STRINGDB
RPH3A
Tbio
Family: Epigenetic
Novelty: 0.01321524
Score: 0.951
Data Source: STRINGDB
RAB6B
Tbio
Family: Enzyme
Novelty: 0.0865097
Score: 0.926
Data Source: STRINGDB
RAB34
Tbio
Family: Enzyme
Novelty: 0.03645677
Score: 0.923
Data Source: STRINGDB
RAB34
Tbio
Novelty: 0.03645677
Score: 0.923
Data Source: STRINGDB
RAB37
Tbio
Family: Enzyme
Novelty: 0.07133253
Score: 0.921
Data Source: STRINGDB
RAB33A
Tbio
Family: Enzyme
Novelty: 0.11617001
Score: 0.92
Data Source: STRINGDB
RAB39B
Tbio
Family: Enzyme
Novelty: 0.02362498
Score: 0.919
Data Source: STRINGDB
RAB26
Tbio
Family: Enzyme
Novelty: 0.12023869
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.51

PubMed score by year
PubTator Score  5.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer