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Tbio
RMI2
RecQ-mediated genome instability protein 2

Protein Summary
Description
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312499
  • ENSP00000310356
  • ENSG00000175643
  • ENST00000572173
  • ENSP00000461206

Symbol
  • C16orf75
  • BLAP18
  • C16orf75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
tissue sample
0.66
transcription factor binding site profile
0.63
transcription factor
0.56
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
RMI1
Tbio
Novelty:  0.01222442
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TOP3A
Tbio
Family:  Enzyme
Novelty:  0.0055546
p_int:  0.999999737
p_ni:  2.61e-7
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
BLM
Tchem
Novelty:  0.00662454
p_int:  0.999367937
p_ni:  0.000632063
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.981769405
p_ni:  4.3e-8
p_wrong:  0.018230552
Score:  0.826
Data Source:  BioPlex,STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.999
Data Source:  STRINGDB
FANCA
Tbio
Novelty:  0.00324947
Score:  0.996
Data Source:  STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
Score:  0.995
Data Source:  STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.993
Data Source:  STRINGDB
GEN1
Tbio
Family:  Enzyme
Novelty:  0.00747874
Score:  0.979
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.979
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Cell Cycle (R-HSA-1640170)

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Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
2
3
0
1.1
94.2
QT interval
6
2
4
1.3
92.4
3
3
0
1.1
92.1
2
2
0
1.1
91.1
allergic disease
2
2
0
1.1
89.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
94.2
QT interval
4
1.3
92.4
0
1.1
92.1
0
1.1
91.1
allergic disease
0
1.1
89.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RecQ mediated genome instability 2
VGNC:9000
738486
Mouse
MGI:2685383
223970
Rat
RGD:1563163
497856
Dog
RecQ mediated genome instability 2
VGNC:45609
609907
Cow
RecQ mediated genome instability 2
VGNC:33994
615553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RecQ mediated genome instability 2
Mouse
Rat
Dog
RecQ mediated genome instability 2
Cow
RecQ mediated genome instability 2
Publication Statistics
PubMed Score 39.61
PubMed score by year
PubTator Score 22.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title