Tbio MRRF Ribosome-recycling factor, mitochondrial

Protein Summary

Description

Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q96E11
• A8K6D8
• A8K6Z4
• B7Z4X5
• B7Z6P7
• Q5RKT1
• Q5T7T0
• Q5T7T1
• Q5T7T2
• Q5T7T3
• Q5T7T4
• Q5T7T5
• RRF

Gene Name

• MRRF

Ensembl ID

• ENST00000297908
• ENSP00000297908
• ENSG00000148187
• ENST00000344641
• ENSP00000343867
• ENST00000373723
• ENSP00000362828
• ENST00000373729
• ENSP00000362834
• ENST00000394315
• ENSP00000377850
• ENST00000467864
• ENSP00000433288
• ENST00000470366
• ENSP00000434807
• ENST00000489572
• ENSP00000436360

Symbol

• RRF
• MRFF
• MTRRF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
kinase perturbation	0.81
virus perturbation	0.72
transcription factor binding site profile	0.7
tissue sample	0.69

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosome-recycling Factor, Mitochondrial

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosome-recycling Factor, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.07   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.07   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0