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Tbio
MRRF
Ribosome-recycling factor, mitochondrial

Protein Summary
Description
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297908
  • ENSP00000297908
  • ENSG00000148187
  • ENST00000344641
  • ENSP00000343867
  • ENST00000373723
  • ENSP00000362828
  • ENST00000373729
  • ENSP00000362834
  • ENST00000394315
  • ENSP00000377850
  • ENST00000467864
  • ENSP00000433288
  • ENST00000470366
  • ENSP00000434807
  • ENST00000489572
  • ENSP00000436360

Symbol
  • RRF
  • MRFF
  • MTRRF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.81
virus perturbation
0.72
transcription factor binding site profile
0.7
tissue sample
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosome recycling factor
VGNC:4792
464712
Macaque
mitochondrial ribosome recycling factor
700902
Mouse
MGI:1915121
67871
Rat
RGD:1305897
311903
Dog
mitochondrial ribosome recycling factor
VGNC:43428
480739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosome recycling factor
Macaque
mitochondrial ribosome recycling factor
Mouse
Rat
Dog
mitochondrial ribosome recycling factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96E11-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation termination
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation termination
Translation
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (265)
1 – 10 of 265
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.997598382
p_ni: 0.002401367
p_wrong: 2.52e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
HCCS
Tbio
Family: Enzyme
Novelty: 0.0022585
p_int: 0.997429145
p_ni: 0.002570855
Score: 0.253
Data Source: BioPlex,STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
p_int: 0.954967895
p_ni: 0.045032097
p_wrong: 8e-9
Score: 0.231
Data Source: BioPlex,STRINGDB
MMAB
Tbio
Family: Enzyme
Novelty: 0.01681296
p_int: 0.921151977
p_ni: 0.078848011
p_wrong: 1.2e-8
Score: 0.28
Data Source: BioPlex,STRINGDB
IBA57
Tbio
Family: Enzyme
Novelty: 0.06327415
p_int: 0.90101434
p_ni: 0.098985659
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
CT55
Tdark
Novelty: 0.20854606
p_int: 0.810977619
p_ni: 0.110771987
p_wrong: 0.078250393
Score: 0.198
Data Source: BioPlex,STRINGDB
GFM2
Tbio
Novelty: 0.02945848
Score: 0.994
Data Source: Reactome,STRINGDB
MRPS9
Tdark
Novelty: 0.22906484
Score: 0.992
Data Source: STRINGDB
MRPL20
Tdark
Novelty: 0.91178993
Score: 0.991
Data Source: STRINGDB
MRPS16
Tbio
Novelty: 0.24108603
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  368.90

PubMed score by year
PubTator Score  100.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer