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Tbio
MRRF
Ribosome-recycling factor, mitochondrial

Protein Summary
Description
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297908
  • ENSP00000297908
  • ENSG00000148187
  • ENST00000344641
  • ENSP00000343867
  • ENST00000373723
  • ENSP00000362828
  • ENST00000373729
  • ENSP00000362834
  • ENST00000394315
  • ENSP00000377850
  • ENST00000467864
  • ENSP00000433288
  • ENST00000470366
  • ENSP00000434807
  • ENST00000489572
  • ENSP00000436360

Symbol
  • RRF
  • MRFF
  • MTRRF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.81
virus perturbation
0.72
transcription factor binding site profile
0.7
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (265)
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.997598382
p_ni:  0.002401367
p_wrong:  2.52e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.997429145
p_ni:  0.002570855
Score:  0.253
Data Source:  BioPlex,STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
p_int:  0.954967895
p_ni:  0.045032097
p_wrong:  8e-9
Score:  0.231
Data Source:  BioPlex,STRINGDB
MMAB
Tbio
Family:  Enzyme
Novelty:  0.01681296
p_int:  0.921151977
p_ni:  0.078848011
p_wrong:  1.2e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
p_int:  0.90101434
p_ni:  0.098985659
p_wrong:  1e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
CT55
Tdark
Novelty:  0.20854606
p_int:  0.810977619
p_ni:  0.110771987
p_wrong:  0.078250393
Score:  0.198
Data Source:  BioPlex,STRINGDB
GFM2
Tbio
Novelty:  0.02945848
Score:  0.994
Data Source:  Reactome,STRINGDB
MRPS9
Tdark
Novelty:  0.22906484
Score:  0.992
Data Source:  STRINGDB
MRPL20
Tdark
Novelty:  0.91178993
Score:  0.991
Data Source:  STRINGDB
MRPS16
Tbio
Novelty:  0.24108603
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation termination
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation termination
Translation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
42.3
1
1
0
1.2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
42.3
0
1.2
31.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosome recycling factor
VGNC:4792
464712
Macaque
mitochondrial ribosome recycling factor
700902
Mouse
MGI:1915121
67871
Rat
RGD:1305897
311903
Dog
mitochondrial ribosome recycling factor
VGNC:43428
480739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosome recycling factor
Macaque
mitochondrial ribosome recycling factor
Mouse
Rat
Dog
mitochondrial ribosome recycling factor
Publication Statistics
PubMed Score 375.56
PubMed score by year
PubTator Score 100.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title