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Tbio
CMTM5
CKLF-like MARVEL transmembrane domain-containing protein 5

Protein Summary
Description
This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339180
  • ENSP00000344819
  • ENSG00000166091
  • ENST00000342473
  • ENSP00000344160
  • ENST00000359320
  • ENSP00000352270
  • ENST00000382809
  • ENSP00000372259
  • ENST00000397227
  • ENSP00000380404
  • ENST00000649278
  • ENSP00000497215

Symbol
  • CKLFSF5
  • CKLFSF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.59
kinase perturbation
0.48
tissue
0.46
transcription factor
0.46
biological term
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CKLF
Tbio
Novelty:  0.01452927
Score:  0.89
Data Source:  STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
Score:  0.769
Data Source:  STRINGDB
CMTM4
Tbio
Novelty:  0.09490151
Score:  0.716
Data Source:  STRINGDB
PRR18
Tdark
Novelty:  1.18933147
Score:  0.671
Data Source:  STRINGDB
CMTM7
Tbio
Novelty:  0.12799659
Score:  0.602
Data Source:  STRINGDB
CMTM2
Tbio
Novelty:  0.07380731
Score:  0.558
Data Source:  STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
Score:  0.547
Data Source:  STRINGDB
FRRS1L
Tbio
Novelty:  0.00607449
Score:  0.546
Data Source:  STRINGDB
AMER3
Tdark
Novelty:  0.42348252
Score:  0.526
Data Source:  STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
Score:  0.512
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
2
1
1
5.3
94.5
electrocardiography
2
1
61
5.3
94.2
pulse pressure measurement
2
2
2
92.5
P wave terminal force measurement
1
1
0
133.5
89.1
2
2
0
1.1
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
1
5.3
94.5
electrocardiography
61
5.3
94.2
pulse pressure measurement
2
92.5
P wave terminal force measurement
0
133.5
89.1
0
1.1
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CKLF like MARVEL transmembrane domain containing 5
VGNC:13038
743982
Macaque
CKLF like MARVEL transmembrane domain containing 5
713886
Mouse
MGI:2447164
67272
Dog
CKLF like MARVEL transmembrane domain containing 5
VGNC:39382
608193
Horse
CKLF like MARVEL transmembrane domain containing 5 [Source:HGNC Symbol;Acc:HGNC:19176]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CKLF like MARVEL transmembrane domain containing 5
Macaque
CKLF like MARVEL transmembrane domain containing 5
Mouse
Dog
CKLF like MARVEL transmembrane domain containing 5
Horse
CKLF like MARVEL transmembrane domain containing 5 [Source:HGNC Symbol;Acc:HGNC:19176]
Publication Statistics
PubMed Score 22.20
PubMed score by year
PubTator Score 13.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title