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Tbio
ERLEC1
Endoplasmic reticulum lectin 1

Protein Summary
Description
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000185150
  • ENSP00000185150
  • ENSG00000068912
  • ENST00000378239
  • ENSP00000367485
  • ENST00000405123
  • ENSP00000385629

Symbol
  • C2orf30
  • XTP3TPB
  • CIM
  • HEL117
  • XTP3-B
  • C2orf30
  • CL24936
  • CL25084
  • XTP3TPB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.88
transcription factor perturbation
0.8
small molecule perturbation
0.68
tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.72   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.72   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0