Tbio MTBP Mdm2-binding protein

Protein Summary

Description

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q96DY7
• B4DUR5
• Q9HA89
• hMTBP

Gene Name

• MTBP

Ensembl ID

• ENST00000305949
• ENSP00000303398
• ENSG00000172167
• ENST00000523373
• ENSP00000430771

Symbol

• MDM2BP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
drug perturbation	0.71
transcription factor binding site profile	0.66
tissue sample	0.65
tissue	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.68   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.68   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0