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Tbio
ASB9
Ankyrin repeat and SOCS box protein 9

Protein Summary
Description
Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380483
  • ENSP00000369850
  • ENSG00000102048
  • ENST00000380485
  • ENSP00000369852
  • ENST00000380488
  • ENSP00000369855
  • ENST00000546332
  • ENSP00000438943
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
cell type or tissue
0.7
tissue sample
0.6
PubMedID
0.59
tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.37   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.37   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
91.4
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (329)
1 – 10 of 329
CKMT1A
Tbio
Family: Kinase
Novelty: 0.00844533
p_int: 0.999803479
p_ni: 0.000196521
Score: 0.93
Data Source: BioPlex,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
p_int: 0.999340186
p_ni: 0.000659814
Score: 0.995
Data Source: BioPlex,STRINGDB
ARIH2
Tbio
Family: Enzyme
Novelty: 0.03455224
p_int: 0.998993768
p_ni: 0.000206592
p_wrong: 0.00079964
Score: 0.927
Data Source: BioPlex,STRINGDB
CKB
Tbio
Family: Kinase
Novelty: 0.00347535
p_int: 0.998523968
p_ni: 0.001476032
Score: 0.97
Data Source: BioPlex,STRINGDB
CKM
Tbio
Family: Kinase
Novelty: 0.00239628
p_int: 0.997078369
p_ni: 0.000023782
p_wrong: 0.002897849
Score: 0.834
Data Source: BioPlex,STRINGDB
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.996094424
p_ni: 0.003905576
Score: 0.974
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.985343879
p_ni: 0.014656121
Score: 0.923
Data Source: BioPlex,STRINGDB
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.983908014
p_ni: 0.016091986
Score: 0.375
Data Source: BioPlex,STRINGDB
ELOB
Tbio
Novelty: 0.01315739
p_int: 0.798468834
p_ni: 0.201531166
Score: 0.993
Data Source: BioPlex,STRINGDB
ASB17
Tbio
Novelty: 0.0979661
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.37

PubMed score by year
PubTator Score  7.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer