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Tdark
RSPRY1
RING finger and SPRY domain-containing protein 1

Protein Summary
Description
This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394420
  • ENSP00000377942
  • ENSG00000159579
  • ENST00000537866
  • ENSP00000443176

Symbol
  • KIAA1972
  • SEMDFA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.75
gene perturbation
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger and SPRY domain containing 1
VGNC:9102
454113
Mouse
MGI:1914860
67610
Rat
RGD:1308847
689249
Dog
ring finger and SPRY domain containing 1
VGNC:45785
478112
Horse
ring finger and SPRY domain containing 1
VGNC:22606
100052133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger and SPRY domain containing 1
Mouse
Rat
Dog
ring finger and SPRY domain containing 1
Horse
ring finger and SPRY domain containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96DX4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
INF2
Tbio
Novelty: 0.00978892
p_int: 0.999996743
p_ni: 2.3e-8
p_wrong: 0.000003234
Score: 0.159
Data Source: BioPlex,STRINGDB
C5orf30
Tdark
Novelty: 0.2072045
p_int: 0.999988724
p_ni: 0.000011045
p_wrong: 2.31e-7
Score: 0.313
Data Source: BioPlex,STRINGDB
NES
Tbio
Novelty: 0.00035379
p_int: 0.999979728
p_ni: 0.000020268
p_wrong: 5e-9
Score: 0.534
Data Source: BioPlex,STRINGDB
INA
Tbio
Novelty: 0.00708581
p_int: 0.999964273
p_ni: 0.000035727
Score: 0.215
Data Source: BioPlex,STRINGDB
XAGE3
Tdark
Novelty: 0.1418603
p_int: 0.999937089
p_ni: 0.000062911
Data Source: BioPlex
UNC119
Tchem
Novelty: 0.00396292
p_int: 0.999678149
p_ni: 0.000321851
Score: 0.158
Data Source: BioPlex,STRINGDB
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.999671966
p_ni: 0.000328034
Data Source: BioPlex
NEFM
Tbio
Novelty: 0.00239134
p_int: 0.999278949
p_ni: 0.000721051
Score: 0.545
Data Source: BioPlex,STRINGDB
NEFL
Tbio
Novelty: 0.00049255
p_int: 0.996353123
p_ni: 0.003646877
Score: 0.313
Data Source: BioPlex,STRINGDB
LYZL1
Tbio
Family: Enzyme
Novelty: 0.10945096
p_int: 0.994177181
p_ni: 0.005822817
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  3.45

PubMed score by year
PubTator Score  1.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer