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Tchem
ITPKC
Inositol-trisphosphate 3-kinase C

Protein Classes
Protein Summary
Description
Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263370
  • ENSP00000263370
  • ENSG00000086544

Symbol
  • IP3KC
  • IP3KC
  • IP3-3KC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
molecular function
0.93
transcription factor
0.84
transcription factor binding site profile
0.75
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.54   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.54   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
GNF362
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (85)
1 – 10 of 85
PIP
Tbio
Novelty: 0.00268794
p_int: 0.999999934
p_ni: 2.7e-8
p_wrong: 3.9e-8
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.00069833
p_int: 0.999999857
p_ni: 1.41e-7
p_wrong: 2e-9
Score: 0.415
Data Source: BioPlex,STRINGDB
RARRES1
Tbio
Family: Enzyme
Novelty: 0.03698309
p_int: 0.999995479
p_ni: 0.000001514
p_wrong: 0.000003007
Data Source: BioPlex
ERP44
Tbio
Novelty: 0.02934854
p_int: 0.993092068
p_ni: 2.6e-8
p_wrong: 0.006907906
Score: 0.239
Data Source: BioPlex,STRINGDB
IPMK
Tbio
Family: Kinase
Novelty: 0.02115444
Score: 0.959
Data Source: STRINGDB
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03832271
Score: 0.948
Data Source: STRINGDB
MINPP1
Tbio
Family: Enzyme
Novelty: 0.03074783
Score: 0.94
Data Source: STRINGDB
OCRL
Tbio
Family: Enzyme
Novelty: 0.0058211
Score: 0.937
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00017995
Score: 0.934
Data Source: STRINGDB
INPP5D
Tbio
Family: Enzyme
Novelty: 0.00819089
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.54

PubMed score by year
PubTator Score  27.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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