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Tbio
SLAMF6
SLAM family member 6

Protein Summary
Description
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell diffe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368055
  • ENSP00000357034
  • ENSG00000162739
  • ENST00000368057
  • ENSP00000357036
  • ENST00000368059
  • ENSP00000357038

Symbol
  • KALI
  • KALI
  • NTBA
  • CD352
  • KALIb
  • Ly108
  • NTB-A
  • SF2000
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
protein domain
0.73
tissue sample
0.66
cell type or tissue
0.63
microRNA
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.92   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.92   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
SH2D1A
Tbio
Novelty:  0.0060687
Score:  0.982
Data Source:  Reactome,STRINGDB
SH2D1B
Tbio
Novelty:  0.01535146
Score:  0.975
Data Source:  Reactome,STRINGDB
NCR3
Tbio
Novelty:  0.00428788
Score:  0.789
Data Source:  STRINGDB
CD48
Tbio
Novelty:  0.00301661
Score:  0.758
Data Source:  STRINGDB
KLRF1
Tbio
Novelty:  0.05732414
Score:  0.756
Data Source:  STRINGDB
CD244
Tbio
Novelty:  0.01137579
Score:  0.752
Data Source:  STRINGDB
KLRK1
Tbio
Novelty:  0.0009209
Score:  0.724
Data Source:  STRINGDB
NCR2
Tbio
Novelty:  0.00685029
Score:  0.708
Data Source:  STRINGDB
CD226
Tbio
Novelty:  0.00374102
Score:  0.7
Data Source:  STRINGDB
SLAMF8
Tbio
Novelty:  0.1485993
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
74.4
1
1
0
1.3
70.2
1
1
0
1.1
60.5
eosinophil percentage of leukocytes
1
1
1
57.3
platelet crit
1
1
1
13
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
74.4
0
1.3
70.2
0
1.1
60.5
eosinophil percentage of leukocytes
1
57.3
platelet crit
1
13
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLAM family member 6
VGNC:1550
746886
Macaque
SLAM family member 6
719728
Mouse
MGI:1353620
30925
Rat
RGD:1561848
498287
Dog
SLAM family member 6
VGNC:46207
100684044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLAM family member 6
Macaque
SLAM family member 6
Mouse
Rat
Dog
SLAM family member 6
Publication Statistics
PubMed Score 69.92
PubMed score by year
PubTator Score 34.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title