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Tbio
DNAH11
Dynein heavy chain 11, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409508
  • ENSP00000475939
  • ENSG00000105877

Symbol
  • CILD7
  • DNHBL
  • DPL11
  • DNAHBL
  • DNAHC11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.99
molecular function
0.93
histone modification site profile
0.72
cell type or tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.35   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.35   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
4
8
99.6
total cholesterol measurement
5
3
5
90.4
2
1
0
1.4
87.4
1
1
0
1.2
84.6
1
1
0
1.2
84.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
99.6
total cholesterol measurement
5
90.4
0
1.4
87.4
0
1.2
84.6
0
1.2
84.6
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (110)
1 – 10 of 110
DNAI1
Tbio
Novelty: 0.01021193
Score: 0.953
Data Source: STRINGDB
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.93
Data Source: STRINGDB
NME8
Tbio
Novelty: 0.05439119
Score: 0.903
Data Source: STRINGDB
CCDC114
Tbio
Novelty: 0.12534741
Score: 0.88
Data Source: STRINGDB
DNAL4
Tbio
Novelty: 0.15546154
Score: 0.865
Data Source: STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
Score: 0.818
Data Source: STRINGDB
DNALI1
Tbio
Novelty: 0.13865981
Score: 0.816
Data Source: STRINGDB
DYNC2LI1
Tbio
Novelty: 0.05087433
Score: 0.811
Data Source: STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
Score: 0.798
Data Source: STRINGDB
RSPH4A
Tbio
Novelty: 0.07992083
Score: 0.797
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.35

PubMed score by year
PubTator Score  18.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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