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Tbio
ARHGEF26
Rho guanine nucleotide exchange factor 26

Protein Summary
Description
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356448
  • ENSP00000348828
  • ENSG00000114790
  • ENST00000465093
  • ENSP00000423418
  • ENST00000465817
  • ENSP00000423295
  • ENST00000496710
  • ENSP00000424446
  • ENST00000614308
  • ENSP00000481927
  • ENSG00000277101
  • ENST00000618535
  • ENSP00000484367
  • ENST00000629129
  • ENSP00000486665
  • ENST00000630729
  • ENSP00000487265

Symbol
  • SGEF
  • SGEF
  • CSGEF
  • HMFN1864
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.78
kinase perturbation
0.71
interacting protein
0.7
microRNA
0.66
small molecule perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.2   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.2   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
86.3
body mass index
4
3
4
86.3
6
4
4
1.1
81.9
6
4
4
1.1
81.9
comparative body size at age 10, self-reported
1
1
1
52
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
86.3
body mass index
4
86.3
4
1.1
81.9
4
1.1
81.9
comparative body size at age 10, self-reported
1
52
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 26
VGNC:53354
470971
Macaque
Rho guanine nucleotide exchange factor 26
708205
Mouse
MGI:1918053
622434
Rat
RGD:1562559
310460
Dog
Rho guanine nucleotide exchange factor 26
VGNC:38082
611857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 26
Macaque
Rho guanine nucleotide exchange factor 26
Mouse
Rat
Dog
Rho guanine nucleotide exchange factor 26
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96DR7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Protein-Protein Interactions (48)
1 – 10 of 48
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.999999866
p_ni:  1.34e-7
Data Source:  BioPlex
LIN7C
Tbio
Novelty:  0.06778878
p_int:  0.999999619
p_ni:  3.81e-7
Score:  0.293
Data Source:  BioPlex,STRINGDB
LIN7B
Tbio
Novelty:  0.12689192
p_int:  0.999995953
p_ni:  0.000004047
Data Source:  BioPlex
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.999829392
p_ni:  0.000170608
Score:  0.197
Data Source:  BioPlex,STRINGDB
DCAF8
Tbio
Novelty:  0.12456534
p_int:  0.991068361
p_ni:  0.006707929
p_wrong:  0.00222371
Data Source:  BioPlex
CPS1
Tclin
Family:  Enzyme
Novelty:  0.00917469
p_int:  0.919778685
p_ni:  0.080221315
Score:  0.211
Data Source:  BioPlex,STRINGDB
CPT2
Tchem
Family:  Enzyme
Novelty:  0.00345645
p_int:  0.885866492
p_ni:  0.114133505
p_wrong:  3e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
PDPR
Tbio
Family:  Enzyme
Novelty:  0.04223174
p_int:  0.812987689
p_ni:  0.187012311
Score:  0.189
Data Source:  BioPlex,STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.981
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  15.20

PubMed score by year
PubTator Score  8.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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