Tbio ARHGEF26 Rho guanine nucleotide exchange factor 26

Protein Summary

Description

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q96DR7
• B3KVP8
• E9PBD0
• Q68CL1
• Q6AZ96
• Q6Q8Q8
• Q96AW8
• Q96DR6
• Q9H9D7
• Q9H9R2
• Q9UFW5

Gene Name

• ARHGEF26

Ensembl ID

• ENST00000356448
• ENSP00000348828
• ENSG00000114790
• ENST00000465093
• ENSP00000423418
• ENST00000465817
• ENSP00000423295
• ENST00000496710
• ENSP00000424446
• ENST00000614308
• ENSP00000481927
• ENSG00000277101
• ENST00000618535
• ENSP00000484367
• ENST00000629129
• ENSP00000486665
• ENST00000630729
• ENSP00000487265

Symbol

• SGEF
• SGEF
• CSGEF
• HMFN1864

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.78
kinase perturbation	0.71
interacting protein	0.7
microRNA	0.66
small molecule perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0