Tbio BPIFA2 BPI fold-containing family A member 2

Protein Summary

Description

Has strong antibacterial activity against P. aeruginosa. This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q96DR5
• Q9BQQ0

Gene Name

• BPIFA2

Ensembl ID

• ENST00000253362
• ENSP00000253362
• ENSG00000131050
• ENST00000354932
• ENSP00000347012

Symbol

• C20orf70
• SPLUNC2
• PSP
• SPLUNC2
• C20orf70
• bA49G10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
cell type or tissue	0.53
tissue sample	0.44
chemical	0.41
biological term	0.34

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.72   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.72   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0