Tbio BPIFA2 BPI fold-containing family A member 2

Protein Summary

Description

Has strong antibacterial activity against P. aeruginosa. This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q96DR5
• Q9BQQ0

Gene Name

• BPIFA2

Ensembl ID

• ENST00000253362
• ENSP00000253362
• ENSG00000131050
• ENST00000354932
• ENSP00000347012

Symbol

• C20orf70
• SPLUNC2
• PSP
• SPLUNC2
• C20orf70
• bA49G10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
cell type or tissue	0.53
tissue sample	0.44
chemical	0.41
biological term	0.34

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.44   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.44   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (37)

Explore Interacting Targets

1 – 10 of 37

• See Interactions on String-DB

FRMD1

Tdark

Novelty:  0.96833141

p_int:  0.999998947

p_ni:  0.000001052

p_wrong:  2e-9

Data Source:  BioPlex

SNRPF

Tdark

Novelty:  0.17624854

p_int:  0.999998569

p_ni:  0.000001431

Data Source:  BioPlex

RHOBTB1

Tbio

Novelty:  0.02152609

p_int:  0.99999716

p_ni:  0.000002813

p_wrong:  2.7e-8

Data Source:  BioPlex

ZNF491

Tdark

Family:  TF

Novelty:  4.75862069

p_int:  0.999984291

p_ni:  0.000015653

p_wrong:  5.6e-8

Score:  0.188

Data Source:  BioPlex,STRINGDB

HINT2

Tbio

Novelty:  0.09560851

p_int:  0.999981139

p_ni:  0.000018785

p_wrong:  7.6e-8

Data Source:  BioPlex

PLEKHG6

Tbio

Novelty:  0.15989022

p_int:  0.999976695

p_ni:  0.000023225

p_wrong:  7.9e-8

Score:  0.169

Data Source:  BioPlex,STRINGDB

COG2

Tbio

Novelty:  0.03109287

p_int:  0.999959734

p_ni:  0.000038772

p_wrong:  0.000001494

Data Source:  BioPlex

ACAD9

Tbio

Family:  Enzyme

Novelty:  0.03238308

p_int:  0.999870228

p_ni:  0.000119633

p_wrong:  0.000010139

Data Source:  BioPlex

KIR2DS2

Tdark

p_int:  0.999810461

p_ni:  0.00017369

p_wrong:  0.00001585

Data Source:  BioPlex

UQCRQ

Tbio

Novelty:  0.04392627

p_int:  0.99965776

p_ni:  0.000320802

p_wrong:  0.000021438

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Antimicrobial peptides (R-HSA-6803157)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Antimicrobial peptides	89 targets	R-HSA-6803157
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (2)

Processes (2)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
lipopolysaccharide binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
suntan	EFO_0004279	1	1	1		87.3
non-melanoma skin carcinoma	EFO_0009260	1	1	0	1.3	56.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
suntan	EFO_0004279	1		87.3
non-melanoma skin carcinoma	EFO_0009260	0	1.3	56.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Antibiotic
Antimicrobial
Complete proteome
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
non-melanoma skin carcinoma
suntan

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	BPI fold containing family A member 2	VGNC:6055	743850
Mouse	BPI fold containing family A, member 2	MGI:97787	19194
Rat	BPI fold containing family A, member 2	RGD:3431	50585
Dog	BPI fold containing family A member 2	VGNC:38505	608599
Horse	BPI fold containing family A member 2	VGNC:15868	100034112

Species	Name	OMA	EggNOG	Inparanoid
Chimp	BPI fold containing family A member 2
Mouse	BPI fold containing family A, member 2
Rat	BPI fold containing family A, member 2
Dog	BPI fold containing family A member 2
Horse	BPI fold containing family A member 2

Publication Statistics

PubMed Score 62.44

PubMed score by year

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PubTator Score 96.09

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (2)

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0 of 0

PMID	Year	Title