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Tbio
MBD6
Methyl-CpG-binding domain protein 6

Protein Summary
Description
Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355673
  • ENSP00000347896
  • ENSG00000166987

Symbol
  • KIAA1887
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
cell line
0.73
transcription factor binding site profile
0.71
transcription factor
0.69
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999969009
p_ni:  1.42e-7
p_wrong:  0.00003085
Data Source:  BioPlex
ASXL2
Tbio
Family:  Epigenetic
Novelty:  0.04277784
p_int:  0.999187301
p_wrong:  0.000812699
Score:  0.98
Data Source:  BioPlex,STRINGDB
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.896320727
p_ni:  2.72e-7
p_wrong:  0.103679001
Score:  0.942
Data Source:  BioPlex,STRINGDB
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
Score:  0.952
Data Source:  STRINGDB
KDM1B
Tbio
Family:  Epigenetic
Novelty:  0.02174039
Score:  0.95
Data Source:  STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
Score:  0.94
Data Source:  STRINGDB
ASXL1
Tbio
Family:  Epigenetic
Novelty:  0.00342965
Score:  0.935
Data Source:  STRINGDB
FOXK1
Tbio
Family:  TF
Novelty:  0.01321144
Score:  0.934
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.908
Data Source:  STRINGDB
HIST1H2AC
Tdark
Novelty:  0.4785744
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
5
8
98.6
high density lipoprotein cholesterol measurement
4
6
10
97.1
apolipoprotein A 1 measurement
2
3
3
91.8
triglyceride measurement
3
4
8
88.7
aspartate aminotransferase measurement
1
1
0
10.3
76.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
8
98.6
high density lipoprotein cholesterol measurement
10
97.1
apolipoprotein A 1 measurement
3
91.8
triglyceride measurement
8
88.7
aspartate aminotransferase measurement
0
10.3
76.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain protein 6
VGNC:5467
452018
Macaque
methyl-CpG binding domain protein 6
711848
Mouse
MGI:106378
110962
Rat
RGD:1311050
362892
Dog
methyl-CpG binding domain protein 6
VGNC:43054
481127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain protein 6
Macaque
methyl-CpG binding domain protein 6
Mouse
Rat
Dog
methyl-CpG binding domain protein 6
Publication Statistics
PubMed Score 6.62
PubMed score by year
PubTator Score 4.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title