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Tbio
CMBL
Carboxymethylenebutenolidase homolog

Protein Summary
Description
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296658
  • ENSP00000296658
  • ENSG00000164237

Symbol
  • JS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.9
transcription factor perturbation
0.88
disease perturbation
0.87
kinase perturbation
0.81
gene perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
FAM173B
Tbio
Novelty:  0.02367461
Score:  0.895
Data Source:  STRINGDB
FSIP2
Tdark
Novelty:  0.16245939
Score:  0.706
Data Source:  STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
Score:  0.697
Data Source:  STRINGDB
SMPDL3A
Tbio
Family:  Enzyme
Novelty:  0.14245461
Score:  0.663
Data Source:  STRINGDB
ASAH2B
Tdark
Family:  Enzyme
Novelty:  0.66932428
Score:  0.649
Data Source:  STRINGDB
ACSF3
Tbio
Family:  Enzyme
Novelty:  0.04255285
Score:  0.647
Data Source:  STRINGDB
ACAA2
Tbio
Family:  Enzyme
Novelty:  0.01452373
Score:  0.643
Data Source:  STRINGDB
BTC
Tbio
Novelty:  0.00673076
Score:  0.64
Data Source:  STRINGDB
NLN
Tbio
Family:  Enzyme
Novelty:  0.01217367
Score:  0.637
Data Source:  STRINGDB
ACADS
Tbio
Family:  Enzyme
Novelty:  0.00841051
Score:  0.634
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carboxymethylenebutenolidase homolog
696762
Mouse
MGI:1916824
69574
Rat
RGD:1306952
310201
Dog
carboxymethylenebutenolidase homolog
VGNC:39376
478619
Horse
carboxymethylenebutenolidase homolog
VGNC:16649
100070903
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carboxymethylenebutenolidase homolog
Mouse
Rat
Dog
carboxymethylenebutenolidase homolog
Horse
carboxymethylenebutenolidase homolog
Publication Statistics
PubMed Score 175.19
PubMed score by year
PubTator Score 39.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title