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Tbio
NUDT16
U8 snoRNA-decapping enzyme

Protein Summary
Description
RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxygua ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000502852
  • ENSP00000422375
  • ENSG00000198585
  • ENST00000521288
  • ENSP00000429274
  • ENST00000537561
  • ENSP00000440230
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.91
histone modification site profile
0.91
kinase perturbation
0.71
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behaviour measurement
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behaviour measurement
1
2.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 16
VGNC:12104
107966544
Macaque
nudix hydrolase 16
717914
Mouse
MGI:1922936
75686
Rat
RGD:1311387
363129
Dog
nudix hydrolase 16
VGNC:44028
610721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 16
Macaque
nudix hydrolase 16
Mouse
Rat
Dog
nudix hydrolase 16
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96DE0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NUDT proteins
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NUDT proteins
Purine catabolism
Gene Ontology Terms (34)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (87)
1 – 10 of 87
NUDT16L1
Tbio
Novelty:  0.05291665
p_int:  0.999999576
p_ni:  1e-9
p_wrong:  4.24e-7
Score:  0.565
Data Source:  BioPlex,STRINGDB
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.999988601
p_ni:  0.000011399
Score:  0.188
Data Source:  BioPlex,STRINGDB
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.99622136
p_ni:  0.00377864
Data Source:  BioPlex
D2HGDH
Tbio
Family:  Enzyme
Novelty:  0.04618268
p_int:  0.992003761
p_ni:  0.00748288
p_wrong:  0.000513359
Data Source:  BioPlex
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.968447248
p_ni:  0.022170305
p_wrong:  0.009382448
Data Source:  BioPlex
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.951934212
p_ni:  0.048065788
Data Source:  BioPlex
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.862517592
p_ni:  0.137482408
Data Source:  BioPlex
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.955
Data Source:  STRINGDB
ADSS
Tchem
Family:  Enzyme
Novelty:  0.0126472
Score:  0.919
Data Source:  STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
Score:  0.917
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.15

PubMed score by year
PubTator Score  20.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer