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Tdark
SHISA4
Protein shisa-4

Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
6
16
96.9
daytime rest measurement
2
2
1
1.1
91.9
waist circumference
2
2
2
78.7
body height
1
1
1
77
2
2
2
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
16
96.9
daytime rest measurement
1
1.1
91.9
waist circumference
2
78.7
body height
1
77
2
73.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
shisa family member 4
VGNC:1547
738980
Macaque
shisa family member 4
708341
Mouse
MGI:1924802
77552
Rat
RGD:1312041
360848
Horse
shisa family member 4 [Source:HGNC Symbol;Acc:HGNC:27139]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
shisa family member 4
Macaque
shisa family member 4
Mouse
Rat
Horse
shisa family member 4 [Source:HGNC Symbol;Acc:HGNC:27139]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96DD7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (19)
1 – 10 of 19
PRRG1
Tbio
Novelty:  0.06326646
Score:  0.81
Data Source:  STRINGDB
GGCX
Tclin
Family:  Enzyme
Novelty:  0.00819484
Score:  0.721
Data Source:  STRINGDB
OR6J1
Tdark
Family:  oGPCR
Novelty:  1.19466667
Score:  0.643
Data Source:  STRINGDB
PTPN18
Tbio
Family:  Enzyme
Novelty:  0.0950339
Score:  0.622
Data Source:  STRINGDB
CHERP
Tbio
Novelty:  0.06955626
Score:  0.607
Data Source:  STRINGDB
RBM22
Tbio
Novelty:  0.0536968
Score:  0.601
Data Source:  STRINGDB
SLC38A10
Tdark
Family:  Transporter
Novelty:  0.47522526
Score:  0.596
Data Source:  STRINGDB
NPEPL1
Tdark
Family:  Enzyme
Novelty:  0.2920032
Score:  0.59
Data Source:  STRINGDB
PLSCR3
Tbio
Family:  Enzyme
Novelty:  0.0630074
Score:  0.555
Data Source:  STRINGDB
PATL1
Tbio
Novelty:  0.10847
Score:  0.522
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.33

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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