OTUB2
Ubiquitin thioesterase OTUB2
Protein Summary
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
- ENST00000203664
- ENSP00000203664
- ENSG00000089723
- ENST00000553723
- ENSP00000451283
- ENST00000617748
- ENSP00000478628
- ENSG00000277276
- ENST00000628711
- ENSP00000487491
- C14orf137
- OTB2
- OTU2
- OTB2
- OTU2
- C14orf137
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.68 | ||
tissue sample | 0.68 | ||
microRNA | 0.67 | ||
virus perturbation | 0.64 | ||
small molecule perturbation | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.23 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 355 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.23 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 355 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (90)
GPBP1
Novelty: 0.18802498
p_int: 0.995696435
p_ni: 0.002032292
p_wrong: 0.002271273
Score: 0.332
Data Source: BioPlex,STRINGDB
CPLX3
Novelty: 0.07332857
p_int: 0.963630474
p_ni: 0.022775281
p_wrong: 0.013594244
Score: 0.195
Data Source: BioPlex,STRINGDB
PSMD10
Family: Enzyme
Novelty: 0.01331382
p_int: 0.771294834
p_ni: 0.228577238
p_wrong: 0.000127928
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Ovarian tumor domain proteases | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deubiquitination | ||||
Metabolism of proteins | ||||
Ovarian tumor domain proteases | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (3)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 2 | 4 | 88.5 | ||||||
eosinophil count | 3 | 2 | 4 | 88.5 | ||||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 86.1 | ||||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 86.1 | ||||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 72.5 | ||||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 88.5 | |||||
eosinophil count | 4 | 88.5 | |||||
eosinophil percentage of leukocytes | 3 | 86.1 | |||||
eosinophil percentage of leukocytes | 3 | 86.1 | |||||
sum of eosinophil and basophil counts | 1 | 72.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 467539 | ||||||
Macaque | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 706795 | ||||||
Mouse | MGI:1915399 | 68149 | ||||||
Rat | RGD:1306688 | 314405 | ||||||
Dog | OTU deubiquitinase, ubiquitin aldehyde binding 2 | VGNC:44183 | 480420 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | OTU deubiquitinase, ubiquitin aldehyde binding 2 | |||||
Macaque | OTU deubiquitinase, ubiquitin aldehyde binding 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | OTU deubiquitinase, ubiquitin aldehyde binding 2 | |||||
Publication Statistics
PubMed Score 119.23
PubMed score by year
PubTator Score 11.14
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
|---|