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Tbio
OTUB2
Ubiquitin thioesterase OTUB2

Protein Summary
Description
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000203664
  • ENSP00000203664
  • ENSG00000089723
  • ENST00000553723
  • ENSP00000451283
  • ENST00000617748
  • ENSP00000478628
  • ENSG00000277276
  • ENST00000628711
  • ENSP00000487491

Symbol
  • C14orf137
  • OTB2
  • OTU2
  • OTB2
  • OTU2
  • C14orf137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
tissue sample
0.68
microRNA
0.67
virus perturbation
0.64
small molecule perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
GPBP1
Tbio
Novelty:  0.18802498
p_int:  0.995696435
p_ni:  0.002032292
p_wrong:  0.002271273
Score:  0.332
Data Source:  BioPlex,STRINGDB
CPLX3
Tbio
Novelty:  0.07332857
p_int:  0.963630474
p_ni:  0.022775281
p_wrong:  0.013594244
Score:  0.195
Data Source:  BioPlex,STRINGDB
PSMD10
Tbio
Family:  Enzyme
Novelty:  0.01331382
p_int:  0.771294834
p_ni:  0.228577238
p_wrong:  0.000127928
Data Source:  BioPlex
RNF128
Tbio
Family:  Enzyme
Novelty:  0.10712495
Score:  0.957
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.954
Data Source:  STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.952
Data Source:  STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.941
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.913
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.907
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
4
88.5
eosinophil count
3
2
4
88.5
eosinophil percentage of leukocytes
2
2
3
86.1
eosinophil percentage of leukocytes
2
2
3
86.1
sum of eosinophil and basophil counts
1
1
1
72.5
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
88.5
eosinophil count
4
88.5
eosinophil percentage of leukocytes
3
86.1
eosinophil percentage of leukocytes
3
86.1
sum of eosinophil and basophil counts
1
72.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase, ubiquitin aldehyde binding 2
467539
Macaque
OTU deubiquitinase, ubiquitin aldehyde binding 2
706795
Mouse
MGI:1915399
68149
Rat
RGD:1306688
314405
Dog
OTU deubiquitinase, ubiquitin aldehyde binding 2
VGNC:44183
480420
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase, ubiquitin aldehyde binding 2
Macaque
OTU deubiquitinase, ubiquitin aldehyde binding 2
Mouse
Rat
Dog
OTU deubiquitinase, ubiquitin aldehyde binding 2
Publication Statistics
PubMed Score 119.23
PubMed score by year
PubTator Score 11.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title