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Tbio
FXYD5
FXYD domain-containing ion transport regulator 5

Protein Classes
Protein Summary
Description
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342879
  • ENSP00000344254
  • ENSG00000089327
  • ENST00000392217
  • ENSP00000376051
  • ENST00000392219
  • ENSP00000376053
  • ENST00000423817
  • ENSP00000393848
  • ENST00000541435
  • ENSP00000443390
  • ENST00000590686
  • ENSP00000465667

Symbol
  • DYSAD
  • IWU1
  • RIC
  • IWU1
  • KCT1
  • OIT2
  • DYSAD
  • HSPC113
  • PRO6241
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
transcription factor perturbation
0.88
kinase perturbation
0.81
histone modification site profile
0.76
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.84   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.84   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (28)
1 – 10 of 28
FXYD6
Tbio
Family: IC
Novelty: 0.05831997
Score: 0.78
Data Source: STRINGDB
FXYD3
Tbio
Family: IC
Novelty: 0.01474759
Score: 0.728
Data Source: STRINGDB
ARHGAP32
Tbio
Family: Enzyme
Novelty: 0.00860524
Score: 0.726
Data Source: STRINGDB
FXYD7
Tbio
Family: IC
Novelty: 0.11184545
Score: 0.719
Data Source: STRINGDB
FXYD4
Tdark
Family: IC
Novelty: 0.156
Score: 0.708
Data Source: STRINGDB
FXYD1
Tbio
Family: IC
Novelty: 0.00176593
Score: 0.673
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.0001303
Score: 0.67
Data Source: STRINGDB
RIT1
Tbio
Family: Enzyme
Novelty: 0.00678854
Score: 0.64
Data Source: STRINGDB
ITGA7
Tbio
Novelty: 0.01962657
Score: 0.635
Data Source: STRINGDB
FXYD2
Tclin
Family: Enzyme
Novelty: 0.02237176
Score: 0.63
Data Source: STRINGDB
Publication Statistics
PubMed Score  450.84

PubMed score by year
PubTator Score  68.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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