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Tbio
RAB39B
Ras-related protein Rab-39B

Protein Summary
Description
Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity). This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking. Mutations in this gene are associated with X-linked cognitive disability. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369454
  • ENSP00000358466
  • ENSG00000155961

Symbol
  • WSN
  • BGMR
  • WSMN
  • MRX72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
virus perturbation
0.76
tissue sample
0.63
protein domain
0.58
microRNA
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.53   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.53   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1
0
1.1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
0
1.1
3.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB39B, member RAS oncogene family
VGNC:7630
741453
Macaque
RAB39B, member RAS oncogene family
703369
Mouse
MGI:1915040
67790
Dog
RAB39B, member RAS oncogene family
VGNC:45281
100684215
Horse
RAB39B, member RAS oncogene family
VGNC:22116
100062885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB39B, member RAS oncogene family
Macaque
RAB39B, member RAS oncogene family
Mouse
Dog
RAB39B, member RAS oncogene family
Horse
RAB39B, member RAS oncogene family
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96DA2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (122)
1 – 10 of 122
WHAMM
Tbio
Novelty:  0.06965013
p_int:  0.999996241
p_ni:  1.06e-7
p_wrong:  0.000003652
Score:  0.26
Data Source:  BioPlex,STRINGDB
CLEC16A
Tbio
Novelty:  0.0212098
p_int:  0.999994226
p_ni:  0.000005664
p_wrong:  1.1e-7
Score:  0.234
Data Source:  BioPlex,STRINGDB
TRIM4
Tbio
Family:  Enzyme
Novelty:  0.11398363
p_int:  0.999037669
p_ni:  0.000962285
p_wrong:  4.5e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
p_int:  0.99594151
p_ni:  0.00405849
p_wrong:  1e-9
Score:  0.216
Data Source:  BioPlex,STRINGDB
KLK8
Tchem
Family:  Enzyme
Novelty:  0.00975023
p_int:  0.993529364
p_ni:  0.006470636
Score:  0.305
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.98396839
p_ni:  0.01603161
Score:  0.18
Data Source:  BioPlex,STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.969310062
p_ni:  0.030689938
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.968521643
p_ni:  0.031478357
Data Source:  BioPlex
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
p_int:  0.966728245
p_ni:  0.033270954
p_wrong:  8.01e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
p_int:  0.952438745
p_ni:  0.047561255
Score:  0.159
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  46.53

PubMed score by year
PubTator Score  18.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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