Tchem HVCN1 Voltage-gated hydrogen channel 1

Protein Summary

Description

Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q96D96
• A8MQ37
• B4DEB3
• F8WCH5
• Q6UW11
• Q96IS5

Gene Name

• HVCN1

Ensembl ID

• ENST00000242607
• ENSP00000242607
• ENSG00000122986
• ENST00000356742
• ENSP00000349181
• ENST00000439744
• ENSP00000412052
• ENST00000548312
• ENSP00000449601
• ENST00000620084
• ENSP00000479812

Symbol

• VSOP
• HV1
• VSOP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.67
transcription factor	0.64
molecular function	0.63
cell line	0.52
cellular component	0.52

Protein Classes

DTO Classes

Protein / Ion Channel / Voltage-gated Proton Channel (Vpc) Family / Voltage-gated Hydrogen Channel 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 713   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 713   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0