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Tchem
HVCN1
Voltage-gated hydrogen channel 1

Protein Summary
Description
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242607
  • ENSP00000242607
  • ENSG00000122986
  • ENST00000356742
  • ENSP00000349181
  • ENST00000439744
  • ENSP00000412052
  • ENST00000548312
  • ENSP00000449601
  • ENST00000620084
  • ENSP00000479812

Symbol
  • VSOP
  • HV1
  • VSOP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
transcription factor
0.64
molecular function
0.63
cell line
0.52
cellular component
0.52


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.42   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.42   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Cd<sup>2+</sup>
no chemical structure image available
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydrogen voltage gated channel 1
VGNC:13147
737161
Macaque
hydrogen voltage gated channel 1
709745
Mouse
MGI:1921346
74096
Rat
RGD:1310788
304485
Dog
hydrogen voltage gated channel 1
VGNC:41842
608547
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydrogen voltage gated channel 1
Macaque
hydrogen voltage gated channel 1
Mouse
Rat
Dog
hydrogen voltage gated channel 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96D96-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
ROS and RNS production in phagocytes
Name
Explore in Pharos
Explore in Source
Fertilization
Immune System
Innate Immune System
Neutrophil degranulation
ROS and RNS production in phagocytes
Protein-Protein Interactions (115)
1 – 10 of 115
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.995240104
p_ni:  0.00072452
p_wrong:  0.004035377
Data Source:  BioPlex
CST1
Tbio
Novelty:  0.02399609
p_int:  0.992922824
p_ni:  0.001618629
p_wrong:  0.005458547
Score:  0.211
Data Source:  BioPlex,STRINGDB
DOK2
Tbio
Novelty:  0.02651438
p_int:  0.967830553
p_ni:  0.026011133
p_wrong:  0.006158314
Score:  0.3
Data Source:  BioPlex,STRINGDB
JCHAIN
Tbio
Novelty:  0.00172454
p_int:  0.966964281
p_ni:  0.005394156
p_wrong:  0.027641563
Score:  0.159
Data Source:  BioPlex,STRINGDB
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.923897325
p_ni:  0.013652692
p_wrong:  0.062449983
Score:  0.21
Data Source:  BioPlex,STRINGDB
MUCL1
Tbio
Novelty:  0.05915667
p_int:  0.87123605
p_ni:  0.128761793
p_wrong:  0.000002156
Score:  0.228
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.849795098
p_ni:  0.001017285
p_wrong:  0.149187617
Data Source:  BioPlex
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.948
Data Source:  STRINGDB
CEACAM1
Tbio
Novelty:  0.0029954
Score:  0.94
Data Source:  STRINGDB
CYBA
Tbio
Novelty:  0.00177762
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  582.42

PubMed score by year
PubTator Score  249.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer