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Tbio
REPS1
RalBP1-associated Eps domain-containing protein 1

Protein Summary
Description
May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258062
  • ENSP00000258062
  • ENSG00000135597
  • ENST00000367663
  • ENSP00000356635
  • ENST00000409812
  • ENSP00000386699
  • ENST00000450536
  • ENSP00000392065

Symbol
  • NBIA7
  • RALBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
disease perturbation
0.83
protein domain
0.73
kinase perturbation
0.66
transcription factor binding site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.41   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.41   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
19.3
albumin:globulin ratio measurement
1
1
1
9.4
high density lipoprotein cholesterol measurement
1
1
1
9.4
apolipoprotein A 1 measurement
1
1
1
8.3
serum non-albumin protein measurement
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
19.3
albumin:globulin ratio measurement
1
9.4
high density lipoprotein cholesterol measurement
1
9.4
apolipoprotein A 1 measurement
1
8.3
serum non-albumin protein measurement
1
7.9
Pathways (5)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (160)
1 – 10 of 160
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999999993
p_ni: 7e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.99999991
p_ni: 9.1e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
AAK1
Tchem
Family: Kinase
Novelty: 0.02438961
p_int: 0.999999846
p_ni: 1.54e-7
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
REPS2
Tbio
Novelty: 0.0741316
p_int: 0.999995566
p_ni: 0.000004263
p_wrong: 1.72e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
AP2S1
Tbio
Novelty: 0.01931502
p_int: 0.999990988
p_ni: 0.000009012
Score: 0.977
Data Source: BioPlex,STRINGDB
BMP2K
Tchem
Family: Kinase
Novelty: 0.10145601
p_int: 0.999981525
p_ni: 0.000018475
Score: 0.977
Data Source: BioPlex,STRINGDB
PNMA1
Tbio
Novelty: 0.06899807
p_int: 0.999941578
p_ni: 0.000051123
p_wrong: 0.000007299
Score: 0.183
Data Source: BioPlex,STRINGDB
CLINT1
Tbio
Novelty: 0.00945381
p_int: 0.999603571
p_ni: 0.000396429
Score: 0.744
Data Source: BioPlex,STRINGDB
HIP1R
Tbio
Novelty: 0.02502713
p_int: 0.99948059
p_ni: 0.00051941
Score: 0.93
Data Source: BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty: 0.23296904
p_int: 0.999095634
p_ni: 0.000904282
p_wrong: 8.3e-8
Score: 0.681
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.41

PubMed score by year
PubTator Score  4.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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