RNF183
E3 ubiquitin-protein ligase RNF183
Protein Summary
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).
- ENST00000297894
- ENSP00000417943
- ENSG00000165188
- ENST00000416588
- ENSP00000420740
- ENST00000441031
- ENSP00000417176
- ENST00000478815
- ENSP00000419454
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.85 | ||
tissue sample | 0.75 | ||
gene perturbation | 0.65 | ||
protein domain | 0.41 | ||
tissue | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.93 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.93 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (30)
Nearest Tclin Targets
Pathways (1)
UniProt (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
UniProt | Protein modification; protein ubiquitination. | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Protein modification; protein ubiquitination. | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood lead measurement | 1 | 2 | 2 | 72.4 | |||||
neutrophil count | 1 | 1 | 1 | 69.4 | |||||
reticulocyte measurement | 2 | 1 | 2 | 62.1 | |||||
myeloid white cell count | 1 | 1 | 1 | 61.4 | |||||
reticulocyte count | 2 | 1 | 2 | 60.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood lead measurement | 2 | 72.4 | |||||
neutrophil count | 1 | 69.4 | |||||
reticulocyte measurement | 2 | 62.1 | |||||
myeloid white cell count | 1 | 61.4 | |||||
reticulocyte count | 2 | 60.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ring finger protein 183 | VGNC:4850 | 464672 | |||||
Macaque | ring finger protein 183 | 705679 | ||||||
Mouse | MGI:1923322 | 76072 | ||||||
Rat | RGD:1564412 | 500474 | ||||||
Horse | ring finger protein 183 | VGNC:22458 | 100050237 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ring finger protein 183 | |||||
Macaque | ring finger protein 183 | |||||
Mouse | ||||||
Rat | ||||||
Horse | ring finger protein 183 | |||||
Publication Statistics
PubMed Score 6.93
PubMed score by year
PubTator Score 1.97
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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