RNF183
E3 ubiquitin-protein ligase RNF183
Protein Summary
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).
- ENST00000297894
- ENSP00000417943
- ENSG00000165188
- ENST00000416588
- ENSP00000420740
- ENST00000441031
- ENSP00000417176
- ENST00000478815
- ENSP00000419454
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.85 | ||
tissue sample | 0.75 | ||
gene perturbation | 0.65 | ||
protein domain | 0.41 | ||
tissue | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.22 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.22 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0